1-((2-(3-chloro-4-fluorobenzyl)-6,7-dihydroxy-1-oxoisoindolin-4-yl)sulfonyl)pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:1-((2-(3-chloro-4-fluorobenzyl)-6,7-dihydroxy-1-oxoisoindolin-4-yl)sulfonyl)pyrrolidine-2-carboxylic acid
CAS No.:1421423-72-4
Molecular Formula:C₂₀H₁₈ClFN₂O₇S
Molecular Weight:484.89
Hs Code.:

Synonyms:1-((2-(3-chloro-4-fluorobenzyl)-6,7-dihydroxy-1-oxoisoindolin-4-yl)sulfonyl)pyrrolidine-2-carboxylic acid

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Chemical Property of 1-((2-(3-chloro-4-fluorobenzyl)-6,7-dihydroxy-1-oxoisoindolin-4-yl)sulfonyl)pyrrolidine-2-carboxylic acid

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Technology Process of 1-((2-(3-chloro-4-fluorobenzyl)-6,7-dihydroxy-1-oxoisoindolin-4-yl)sulfonyl)pyrrolidine-2-carboxylic acid

There total 3 articles about 1-((2-(3-chloro-4-fluorobenzyl)-6,7-dihydroxy-1-oxoisoindolin-4-yl)sulfonyl)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₂ClFN₂O₇S

: 1421423-72-4
1-((2-(3-chloro-4-fluorobenzyl)-6,7-dihydroxy-1-oxoisoindolin-4-yl)sulfonyl)pyrrolidine-2-carboxylic acid

Guidance literature:: C₂₂H₂₂ClFN₂O₇S; With boron tribromide; In dichloromethane; for 1h;

With water; In dichloromethane; Cooling with ice;

Reference yield:

: 1027346-78-6
2,3-dihydro-6,7-dimethoxy-2-[(3-chloro-4-fluorophenyl)methyl]-1H-isoindol-1-one

: 1421423-72-4
1-((2-(3-chloro-4-fluorobenzyl)-6,7-dihydroxy-1-oxoisoindolin-4-yl)sulfonyl)pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: chlorosulfonic acid / 1 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran / 20 °C

3.1: boron tribromide / dichloromethane / 1 h

3.2: Cooling with ice

With chlorosulfonic acid; boron tribromide; sodium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1415689-62-1
2-(3-chloro-4-fluorobenzyl)-6,7-dimethoxy-1-oxoisoindoline-4-sulfonyl chloride

: 1421423-72-4
1-((2-(3-chloro-4-fluorobenzyl)-6,7-dihydroxy-1-oxoisoindolin-4-yl)sulfonyl)pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran / 20 °C

2.1: boron tribromide / dichloromethane / 1 h

2.2: Cooling with ice

With boron tribromide; sodium hydroxide; In tetrahydrofuran; dichloromethane;