2,3-dihydro-6,7-dimethoxy-2-[(3-chloro-4-fluorophenyl)methyl]-1H-isoindol-1-one

Base Information

Chemical Name:2,3-dihydro-6,7-dimethoxy-2-[(3-chloro-4-fluorophenyl)methyl]-1H-isoindol-1-one
CAS No.:1027346-78-6
Molecular Formula:C₁₇H₁₅ClFNO₃
Molecular Weight:335.762
Hs Code.:

Synonyms:2,3-dihydro-6,7-dimethoxy-2-[(3-chloro-4-fluorophenyl)methyl]-1H-isoindol-1-one

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Chemical Property of 2,3-dihydro-6,7-dimethoxy-2-[(3-chloro-4-fluorophenyl)methyl]-1H-isoindol-1-one

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Technology Process of 2,3-dihydro-6,7-dimethoxy-2-[(3-chloro-4-fluorophenyl)methyl]-1H-isoindol-1-one

There total 5 articles about 2,3-dihydro-6,7-dimethoxy-2-[(3-chloro-4-fluorophenyl)methyl]-1H-isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 106367-88-8
6-(chloromethyl)-2,3-dimethoxybenzoic acid methyl ester

: 72235-56-4
3-chloro-4-fluorobenzylamine

: 1027346-78-6
2,3-dihydro-6,7-dimethoxy-2-[(3-chloro-4-fluorophenyl)methyl]-1H-isoindol-1-one

Guidance literature:: With triethylamine; In acetonitrile; Heating;
DOI:10.1021/jm070715d

Reference yield: 21.0%

: 1027346-78-6
2,3-dihydro-6,7-dimethoxy-2-[(3-chloro-4-fluorophenyl)methyl]-1H-isoindol-1-one

Guidance literature:

Reference yield:

: 3840-28-6
1,2-dimethoxy-4-(methoxymethyl)benzene

: 1027346-78-6
2,3-dihydro-6,7-dimethoxy-2-[(3-chloro-4-fluorophenyl)methyl]-1H-isoindol-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; diethyl ether / 1 h / 0 °C

1.2: -78 - 20 °C

2.1: acetyl chloride; zinc(II) chloride / diethyl ether / 0.5 h / 0 °C

3.1: triethylamine / acetonitrile / Reflux

With n-butyllithium; triethylamine; acetyl chloride; zinc(II) chloride; In diethyl ether; hexane; acetonitrile;
DOI:10.1016/j.bmcl.2012.10.088