(2R)-1-(hexyloxy)-3-<(4-methoxyphenyl)diphenylmethoxy>-2-propyl thiobenzoate

Base Information

Chemical Name:(2R)-1-(hexyloxy)-3-<(4-methoxyphenyl)diphenylmethoxy>-2-propyl thiobenzoate
CAS No.:161392-05-8
Molecular Formula:C₃₆H₄₀O₄S
Molecular Weight:568.777
Hs Code.:

Synonyms:(2R)-1-(hexyloxy)-3-<(4-methoxyphenyl)diphenylmethoxy>-2-propyl thiobenzoate

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Chemical Property of (2R)-1-(hexyloxy)-3-<(4-methoxyphenyl)diphenylmethoxy>-2-propyl thiobenzoate

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Technology Process of (2R)-1-(hexyloxy)-3-<(4-methoxyphenyl)diphenylmethoxy>-2-propyl thiobenzoate

There total 7 articles about (2R)-1-(hexyloxy)-3-<(4-methoxyphenyl)diphenylmethoxy>-2-propyl thiobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 98-88-4
benzoyl chloride

: 161392-04-7
(2R)-1-(hexyloxy)-3-<(4-methoxyphenyl)diphenylmethoxy>-2-propanethiol

: 161392-05-8
(2R)-1-(hexyloxy)-3-<(4-methoxyphenyl)diphenylmethoxy>-2-propyl thiobenzoate

Guidance literature:: With pyridine; at 25 ℃; for 14h;
DOI:10.1021/jm00050a009

Reference yield:

: 111-25-1
1-bromo-hexane

: 161392-05-8
(2R)-1-(hexyloxy)-3-<(4-methoxyphenyl)diphenylmethoxy>-2-propyl thiobenzoate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) DMF, 45 min, 2.) DMF, 25 deg C, 14 h

2: 100 percent / 1 N HCl / methanol / 24 h / 25 °C

3: 92 percent / pyridine / tetrahydrofuran / 14 h / 25 °C

4: 71 percent / pyridine / CH₂Cl₂ / 14 h / 25 °C

5: 70 percent / dimethylformamide / 16 h / 80 °C

6: 100 percent / NaBH₄ / ethanol / 1 h / 55 °C

7: 67 percent / pyridine / 14 h / 25 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00050a009

Reference yield:

: 86158-13-6
(2S)-3-(hexyloxy)-1,2-propanediol

: 161392-05-8
(2R)-1-(hexyloxy)-3-<(4-methoxyphenyl)diphenylmethoxy>-2-propyl thiobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / pyridine / tetrahydrofuran / 14 h / 25 °C

2: 71 percent / pyridine / CH₂Cl₂ / 14 h / 25 °C

3: 70 percent / dimethylformamide / 16 h / 80 °C

4: 100 percent / NaBH₄ / ethanol / 1 h / 55 °C

5: 67 percent / pyridine / 14 h / 25 °C

With pyridine; sodium tetrahydroborate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00050a009