8-benzoyl-3-methyl-2,3,7,8,9,10-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline

Base Information

Chemical Name:8-benzoyl-3-methyl-2,3,7,8,9,10-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline
CAS No.:1576240-10-2
Molecular Formula:C₂₁H₂₁N₃O
Molecular Weight:331.417
Hs Code.:

Synonyms:8-benzoyl-3-methyl-2,3,7,8,9,10-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline

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Chemical Property of 8-benzoyl-3-methyl-2,3,7,8,9,10-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline

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Technology Process of 8-benzoyl-3-methyl-2,3,7,8,9,10-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline

There total 1 articles about 8-benzoyl-3-methyl-2,3,7,8,9,10-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1576240-09-9
3-methyl-2,3,7,8,9,10-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline

: 98-88-4
benzoyl chloride

: 1576240-10-2
8-benzoyl-3-methyl-2,3,7,8,9,10-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1021/jm401958n

Reference yield:

: 1576240-10-2
8-benzoyl-3-methyl-2,3,7,8,9,10-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline

: 1576240-11-3
8-benzyl-3-methyl-2,3,7,8,9,10-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 - 70 ℃; for 0.5h;
DOI:10.1021/jm401958n

Reference yield:

: 1576240-10-2
8-benzoyl-3-methyl-2,3,7,8,9,10-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline

: (trans)-8-benzyl-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 20 - 70 °C

2.1: borane-THF / tetrahydrofuran / 1 h / Reflux

2.2: 1 h / 94 °C

With lithium aluminium tetrahydride; borane-THF; In tetrahydrofuran;
DOI:10.1021/jm401958n