[1-benzyl-2-(2-chloro-acetylamino)-3-phenyl-propyl]-carbamic acid cyclopentyl ester

Base Information

Chemical Name:[1-benzyl-2-(2-chloro-acetylamino)-3-phenyl-propyl]-carbamic acid cyclopentyl ester
CAS No.:922723-60-2
Molecular Formula:C₂₄H₂₉ClN₂O₃
Molecular Weight:428.959
Hs Code.:

Synonyms:[1-benzyl-2-(2-chloro-acetylamino)-3-phenyl-propyl]-carbamic acid cyclopentyl ester

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Chemical Property of [1-benzyl-2-(2-chloro-acetylamino)-3-phenyl-propyl]-carbamic acid cyclopentyl ester

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Technology Process of [1-benzyl-2-(2-chloro-acetylamino)-3-phenyl-propyl]-carbamic acid cyclopentyl ester

There total 9 articles about [1-benzyl-2-(2-chloro-acetylamino)-3-phenyl-propyl]-carbamic acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 922723-59-9
(2-amino-1-benzyl-3-phenyl-propyl)-carbamic acid cyclopentyl ester

: 79-04-9
chloroacetyl chloride

: 922723-60-2
[1-benzyl-2-(2-chloro-acetylamino)-3-phenyl-propyl]-carbamic acid cyclopentyl ester

Guidance literature:: With triethanolamine; In water; toluene; at 20 ℃; for 0.5h;
DOI:10.1021/jm060754+

Reference yield:

: 6921-34-2
benzylmagnesium chloride

: 922723-60-2
[1-benzyl-2-(2-chloro-acetylamino)-3-phenyl-propyl]-carbamic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: CuBr*DMS / tetrahydrofuran / 0.17 h / -78 °C

1.2: tetrahydrofuran / -78 - 20 °C

2.1: 91 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

3.1: 64 percent / NaN₃ / dimethylformamide / 16 h / 60 °C

4.1: trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 0 °C

5.1: triethanolamine / toluene; H₂O / 1 h / 20 °C

6.1: 99 percent / H₂ / Pd(OH)2/C

7.1: 94 percent / triethanolamine / toluene; H₂O / 0.5 h / 20 °C

With sodium azide; copper(I) bromide dimethylsulfide complex; triethanolamine; hydrogen; triethylamine; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm060754+

Reference yield:

: 922723-30-6
2-azido-1-benzyl-3-phenyl-propylamine

: 922723-60-2
[1-benzyl-2-(2-chloro-acetylamino)-3-phenyl-propyl]-carbamic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethanolamine / toluene; H₂O / 1 h / 20 °C

2: 99 percent / H₂ / Pd(OH)2/C

3: 94 percent / triethanolamine / toluene; H₂O / 0.5 h / 20 °C

With triethanolamine; hydrogen; palladium dihydroxide; In water; toluene;
DOI:10.1021/jm060754+