2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetic acid

Base Information

Chemical Name:2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetic acid
CAS No.:1346502-15-5
Molecular Formula:C₈H₁₅BrO₅
Molecular Weight:271.108
Hs Code.:

Synonyms:2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetic acid

Suppliers and Price of 2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

BroadPharm
Bromo-PEG3-CH2CO2H 98%
250 MG
$ 540.00

Activate Scientific
Br-PEG3-CH2COOH 97%
250 mg
$ 283.00

Acrotein
Br-PEG3-CH2COOH 97%
1g
$ 907.50

Acrotein
Br-PEG3-CH2COOH 97%
0.5g
$ 302.50

Total 6 raw suppliers

Chemical Property of 2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetic acid

Chemical Property:

Boiling Point:379.7±27.0 °C(Predicted)
Density:1.446±0.06 g/cm3(Predicted)

Purity/Quality:

99.3% ^*data from raw suppliers

Bromo-PEG3-CH2CO2H 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Bromo-PEG3-CH2CO2H is a PEG linker containing a bromide group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions.

Technology Process of 2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetic acid

There total 3 articles about 2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 308085-31-6
ethyl 2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetate

: 1346502-15-5
2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetic acid

Guidance literature:: ethyl 2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetate; With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water;
DOI:10.1021/jm2009106

Reference yield:

: 118988-04-8
ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-acetate

: 1346502-15-5
2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 2 h / 0 °C

2: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

With N-Bromosuccinimide; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm2009106

Reference yield:

: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

: 1346502-15-5
2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate / dichloromethane / 2 h / 0 - 20 °C

2: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 2 h / 0 °C

3: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

With N-Bromosuccinimide; boron trifluoride diethyl etherate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm2009106