2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide

Base Information

Chemical Name:2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide
CAS No.:1346502-03-1
Molecular Formula:C₅₆H₇₈FN₇O₁₄
Molecular Weight:1092.27
Hs Code.:

2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide

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Chemical Property of 2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide

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Technology Process of 2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide

There total 18 articles about 2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1346502-25-7
N,N-bis(2-(((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-oxoethyl)-2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)acetamide

: 1346502-03-1
2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide

Guidance literature:: With dimethylsulfide; trifluoroacetic acid; at 20 ℃; for 1h;
DOI:10.1021/jm2009106

Reference yield:

: 69045-79-0
2-choro-5-iodopyridine

: 1346502-03-1
2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 150 °C / Microwave irradiation

2.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 0.83 h / 0 - 20 °C

4.1: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C

5.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

5.2: 60 °C

6.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 70 °C

8.1: dimethylsulfide; trifluoroacetic acid / 1 h / 20 °C

With dmap; sodium azide; dimethylsulfide; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; palladium diacetate; potassium carbonate; caesium carbonate; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm2009106

Reference yield:

: 937183-61-4
4-N-(tert-butyloxycarbonyl)-4-N-methylaminostyrene

: 1346502-03-1
2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 0.83 h / 0 - 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C

4.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

4.2: 60 °C

5.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 70 °C

7.1: dimethylsulfide; trifluoroacetic acid / 1 h / 20 °C

With dmap; sodium azide; dimethylsulfide; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; palladium diacetate; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm2009106