2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide

Base Information

• Chemical Name: 2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide
• CAS No.: 1346502-03-1
• Molecular Formula: C₅₆H₇₈FN₇O₁₄
• Molecular Weight: 1092.27
• Mol file: 1346502-03-1.mol

Synonyms:

Chemical Property of 2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide

There total 18 articles about 2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

N,N-bis(2-(((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-oxoethyl)-2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)acetamide (1346502-25-7) → 2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide (1346502-03-1)

Guidance literature:

With dimethylsulfide; trifluoroacetic acid; at 20 ℃; for 1h;

DOI:10.1021/jm2009106

Reference yield:

2-choro-5-iodopyridine (69045-79-0) → 2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide (1346502-03-1)

Guidance literature:

Multi-step reaction with 8 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 150 °C / Microwave irradiation

2.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 0.83 h / 0 - 20 °C

4.1: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C

5.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

5.2: 60 °C

6.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 70 °C

8.1: dimethylsulfide; trifluoroacetic acid / 1 h / 20 °C

With dmap; sodium azide; dimethylsulfide; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; palladium diacetate; potassium carbonate; caesium carbonate; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm2009106

Reference yield:

4-N-(tert-butyloxycarbonyl)-4-N-methylaminostyrene (937183-61-4) → 2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide (1346502-03-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 0.83 h / 0 - 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C

4.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

4.2: 60 °C

5.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 70 °C

7.1: dimethylsulfide; trifluoroacetic acid / 1 h / 20 °C

With dmap; sodium azide; dimethylsulfide; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; palladium diacetate; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm2009106

upstream raw materials:

2-choro-5-iodopyridine

4-N-(tert-butyloxycarbonyl)-4-N-methylaminostyrene

ethyl 2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetate

2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetic acid