Phosphoric acid 2-chloro-phenyl ester (R)-3-hexadecyloxy-2-methoxy-propyl ester

Base Information

• Chemical Name: Phosphoric acid 2-chloro-phenyl ester (R)-3-hexadecyloxy-2-methoxy-propyl ester
• CAS No.: 342883-88-9
• Molecular Formula: C₂₆H₄₆ClO₆P
• Molecular Weight: 521.074
• Mol file: 342883-88-9.mol

Synonyms:Phosphoric acid 2-chloro-phenyl ester (R)-3-hexadecyloxy-2-methoxy-propyl ester

Chemical Property of Phosphoric acid 2-chloro-phenyl ester (R)-3-hexadecyloxy-2-methoxy-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Phosphoric acid 2-chloro-phenyl ester (R)-3-hexadecyloxy-2-methoxy-propyl ester

There total 3 articles about Phosphoric acid 2-chloro-phenyl ester (R)-3-hexadecyloxy-2-methoxy-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-O-hexadecyl-2-O-methyl-sn-glycerol (96960-92-8,111188-59-1) + 2-chlorophenyl dichlorophosphate (15074-54-1) → Phosphoric acid 2-chloro-phenyl ester (R)-3-hexadecyloxy-2-methoxy-propyl ester (342883-88-9)

Guidance literature:

2-chlorophenyl dichlorophosphate; With 1,2,4-Triazole; triethylamine; In acetonitrile; at 20 ℃; for 0.5h;

1-O-hexadecyl-2-O-methyl-sn-glycerol; With pyridine; In acetonitrile; for 0.75h; Further stages.;

DOI:10.1021/jm001121c

Reference yield:

1-hexadecyl-2-methyl-3-(triphenylmethyl)-sn-glycerol (111247-99-5,162870-36-2) → Phosphoric acid 2-chloro-phenyl ester (R)-3-hexadecyloxy-2-methoxy-propyl ester (342883-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HCOOH / diethyl ether / 3 h / 20 °C

2.1: 1,2,4-triazole; Et₃N / acetonitrile / 0.5 h / 20 °C

2.2: pyridine / acetonitrile / 0.75 h

With 1,2,4-Triazole; formic acid; triethylamine; In diethyl ether; acetonitrile;

DOI:10.1021/jm001121c

Reference yield:

hexadecanyl bromide (112-82-3) → Phosphoric acid 2-chloro-phenyl ester (R)-3-hexadecyloxy-2-methoxy-propyl ester (342883-88-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / toluene / 0.5 h / 0 °C

1.2: KI / toluene / 12 h / 100 °C

2.1: HCOOH / diethyl ether / 3 h / 20 °C

3.1: 1,2,4-triazole; Et₃N / acetonitrile / 0.5 h / 20 °C

3.2: pyridine / acetonitrile / 0.75 h

With 1,2,4-Triazole; formic acid; sodium hydride; triethylamine; In diethyl ether; toluene; acetonitrile;

DOI:10.1021/jm001121c

upstream raw materials:

1-O-hexadecyl-2-O-methyl-sn-glycerol

2-chlorophenyl dichlorophosphate

1-hexadecyl-2-methyl-3-(triphenylmethyl)-sn-glycerol

hexadecanyl bromide

Downstream raw materials:

2-chlorophenyl 5'-(3'-azido-3'-deoxythymidinyl)-1-hexadecyl-2-methoxy-sn-glyceryl phosphate