2-Chlorophenyl phosphorodichloridate

Base Information

• Chemical Name: 2-Chlorophenyl phosphorodichloridate
• CAS No.: 15074-54-1
• Molecular Formula: C6H4Cl3O2P
• Molecular Weight: 245.429
• Hs Code.: 29199000
• European Community (EC) Number: 239-129-4
• UNII: YH4YQB3GEF
• DSSTox Substance ID: DTXSID90164600
• Nikkaji Number: J150.102J
• Wikidata: Q83033659
• Mol file: 15074-54-1.mol

Synonyms:2-Chlorophenyl phosphorodichloridate;15074-54-1;2-Chlorophenyl dichlorophosphate;Phosphorodichloridic acid, 2-chlorophenyl ester;o-Chlorophenyl dichlorophosphate;1-chloro-2-dichlorophosphoryloxybenzene;2-Chlorophenylphosphoryl Dichloride;YH4YQB3GEF;2-Chlorophenyl phosphorodichloridate, tech grade;o-chlorophenyl phosphorodichloridate;EINECS 239-129-4;(2-Chlorophenyl)phosphoric acid dichloride;pyromelliticdianhydride;UNII-YH4YQB3GEF;SCHEMBL1377760;DTXSID90164600;o-Chlorophenylphosphonyl dichloride;2-Chlorophenyl dichloridophosphate #;MFCD00009704;AKOS015888982;2-Chlorophenyl phosphorodichloridate, 99%;C0976;CS-0204799;FT-0611994;D89337;A884139;J-008737;F0001-0537

Chemical Property of 2-Chlorophenyl phosphorodichloridate

Chemical Property:

• Appearance/Colour: Colorless liquid
• Vapor Pressure: 0.0113mmHg at 25°C
• Refractive Index: n20/D 1.538(lit.)
• Boiling Point: 270.5 °C at 760 mmHg
• Flash Point: 136 °C
• PSA: 36.11000
• Density: 1.575 g/cm³
• LogP: 4.30450
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 243.901449
• Heavy Atom Count: 12
• Complexity: 193

Purity/Quality:

97% ^*data from raw suppliers

2-Chlorophenyl phosphorodichloridate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)OP(=O)(Cl)Cl)Cl
• Uses: Phosphorylating reagent for oligonucleotide synthesis via the triester method.1 2-Chlorophenyl phosphorodichloridate has been used in the preparation of:mononucleotide building blocksoligonucleotides and oligonucleotide phosphorothioates in solution

Technology Process of 2-Chlorophenyl phosphorodichloridate

There total 5 articles about 2-Chlorophenyl phosphorodichloridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

sodium 2-chlorophenoxide (35535-81-0) → 2-chlorophenyl dichlorophosphate (15074-54-1)

Guidance literature:

With tetrabutylammomium bromide; trichlorophosphate; In toluene; for 1h;

Reference yield: 50.0%

2-monochlorophenol (95-57-8) → 2-chlorophenyl dichlorophosphate (15074-54-1)

Guidance literature:

With lithium chloride; trichlorophosphate; for 48h; Reflux;

DOI:10.1016/j.poly.2010.04.002

Reference yield:

2-dichlorophosphoryloxy-benzenesulfonyl chloride → 2-chlorophenyl dichlorophosphate (15074-54-1)

Guidance literature:

With phosphorus pentachloride; at 150 ℃;

upstream raw materials:

2-monochlorophenol

sodium 2-chlorophenoxide

phosphorus pentachloride

Downstream raw materials:

2',3'-Di-O-isopropylidene-6-methylthiopurine riboside 5'-(2-chlorophenyl, 2-cyanoethyl)-phosphate

N²-(p-anisyldiphenylmethyl)-9-[(2-hydroxyethoxy)methyl]guanine 2-chlorophenyl (3-hexadecyloxypropyl) phosphate

Phosphorochloridic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester