methyl 4-<2-<<1-<5-chloro-2-dimethylamino-phenyl>ethyl>amino>-2-oxoethyl>-benzoate

Base Information

Chemical Name:methyl 4-<2-<<1-<5-chloro-2-dimethylamino-phenyl>ethyl>amino>-2-oxoethyl>-benzoate
CAS No.:83894-67-1
Molecular Formula:C₂₀H₂₃ClN₂O₃
Molecular Weight:374.867
Hs Code.:

Synonyms:methyl 4-<2-<<1-<5-chloro-2-dimethylamino-phenyl>ethyl>amino>-2-oxoethyl>-benzoate

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Chemical Property of methyl 4-<2-<<1-<5-chloro-2-dimethylamino-phenyl>ethyl>amino>-2-oxoethyl>-benzoate

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Technology Process of methyl 4-<2-<<1-<5-chloro-2-dimethylamino-phenyl>ethyl>amino>-2-oxoethyl>-benzoate

There total 10 articles about methyl 4-<2-<<1-<5-chloro-2-dimethylamino-phenyl>ethyl>amino>-2-oxoethyl>-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23082-50-0
2'-chloro-5'-nitroacetophenone

: 83894-67-1
methyl 4-<2-<<1-<5-chloro-2-dimethylamino-phenyl>ethyl>amino>-2-oxoethyl>-benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 1.5 h / Heating

2: H₂ / 10 percent Pd/C / dimethylformamide / 2 h / 750.06 Torr / Ambient temperature

3: 1.) aq. NaNO₂, HCl, 2.) Cu₂Cl₂, HCl / 1.) from 0 deg C to 5 deg C, 2.) from 0 deg C to 50 deg C

4: 1.) ammonium formiate, 2.) HCl / 1.) 150 deg C, 5 h, 2.) reflux, 3.5 h

5: 1.) N,N'-carbonyldiimidazole / 1.) THF, reflux, 1 h, 2.) THF, RT, overnight

With copper(I) chloride; hydrogenchloride; hydrogen; ammonium formate; 1,1'-carbonyldiimidazole; sodium nitrite; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm9810349

Reference yield:

: 133659-66-2
1-(2-dimethylamino-5-nitro-phenyl)-ethanone

: 83894-67-1
methyl 4-<2-<<1-<5-chloro-2-dimethylamino-phenyl>ethyl>amino>-2-oxoethyl>-benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10 percent Pd/C / dimethylformamide / 2 h / 750.06 Torr / Ambient temperature

2: 1.) aq. NaNO₂, HCl, 2.) Cu₂Cl₂, HCl / 1.) from 0 deg C to 5 deg C, 2.) from 0 deg C to 50 deg C

3: 1.) ammonium formiate, 2.) HCl / 1.) 150 deg C, 5 h, 2.) reflux, 3.5 h

4: 1.) N,N'-carbonyldiimidazole / 1.) THF, reflux, 1 h, 2.) THF, RT, overnight

With copper(I) chloride; hydrogenchloride; hydrogen; ammonium formate; 1,1'-carbonyldiimidazole; sodium nitrite; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1021/jm9810349