Technology Process of (E)-methyl 2,2,6,13-tetramethyl-9-methylene-7,12,15-trioxo-3,3-diphenyl-4-oxa-8,13,16-triaza-3-silaoctadec-10-en-18-oate
There total 8 articles about (E)-methyl 2,2,6,13-tetramethyl-9-methylene-7,12,15-trioxo-3,3-diphenyl-4-oxa-8,13,16-triaza-3-silaoctadec-10-en-18-oate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 2-(2-(2-(diethoxyphosphoryl)-N-methylacetamido)acetamido)acetate;
With
1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride;
In
acetonitrile;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
3-((tert-butyldiphenylsilyl)oxy)-2-methyl-N-(3-oxoprop-1-en-2-yl)propanamide;
In
dichloromethane;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1039/c1cc15829e
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1H-imidazole / dichloromethane / 12 h / 20 °C / Inert atmosphere
2.1: sodium hydroxide / ethanol; water / 14 h / 20 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C / Inert atmosphere
4.2: 1.08 h / -78 - -15 °C / Inert atmosphere
4.3: -15 °C / Inert atmosphere
5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.17 h / 20 °C / Inert atmosphere
5.2: 4 h / 20 °C / Inert atmosphere
With
1H-imidazole; oxalyl dichloride; benzotriazol-1-ol; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium chloride; sodium hydroxide;
In
ethanol; dichloromethane; water; acetonitrile;
5.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1039/c1cc15829e
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C / Inert atmosphere
2.2: 1.08 h / -78 - -15 °C / Inert atmosphere
2.3: -15 °C / Inert atmosphere
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.17 h / 20 °C / Inert atmosphere
3.2: 4 h / 20 °C / Inert atmosphere
With
oxalyl dichloride; benzotriazol-1-ol; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium chloride;
In
dichloromethane; acetonitrile;
3.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1039/c1cc15829e
