820963-51-7Relevant articles and documents
New Strategy for Forging Contiguous Quaternary Carbon Centers via H 2 O 2 -Mediated Ring Contraction
Hu, Jiadong,Yu, Xin,Xie, Weiqing
, p. 2517 - 2524 (2017/09/28)
Stereospecific construction of contiguous quaternary carbon centers constitutes a major challenge in natural product synthesis. A general protocol that enables stereospecific construction of all stereoisomers of such a moiety remains elusive. In this article, we will discuss the oxidative ring contraction of all-substituted cyclic α-formyl ketones mediated by H 2 O 2, which provides a facile access to the stereospecific construction of contiguous quaternary carbon centers.
A concise route to the macrocyclic core of the rakicidins
Poulsen, Thomas B.
supporting information; experimental part, p. 12837 - 12839 (2012/01/06)
An efficient synthesis of the macrolactone core of the rakicidins is described. The rakicidins are cytotoxic lipopeptides with interesting cancer cell selectivities including HIF-1-independent hypoxia-selective cytotoxicity and anti-invasive activity. Access to the core may now allow establishment of preliminary SAR and exploration of routes to several members of rakicidins.
Intramolecular Amidoalkylation of Chiral Iminium Ions: Stereoselective Synthesis of syn-1,3-Aminoalcohols
Hioki, Hideaki,Okuda, Manabu,Miyagi, Waka,Ito, Sho
, p. 6131 - 6134 (2007/10/02)
The intramolecular Hosomi-Sakurai reaction of 3-siloxybutaniminium salts exhibited a syn selectivity of up to 51:1, while the same type of reaction of 2-methyl-3-siloxypropaniminium salts showed up to 290:1 syn selectivity.
