N-(4'-hydroxy-3'-methoxy-benzylidene)-4-methoxybenzoic acid hydrazide

Base Information

• Chemical Name: N-(4'-hydroxy-3'-methoxy-benzylidene)-4-methoxybenzoic acid hydrazide
• CAS No.: 77218-64-5
• Molecular Formula: C₁₆H₁₆N₂O₄
• Molecular Weight: 300.314
• Mol file: 77218-64-5.mol

Synonyms:N-(4'-hydroxy-3'-methoxy-benzylidene)-4-methoxybenzoic acid hydrazide

Chemical Property of N-(4'-hydroxy-3'-methoxy-benzylidene)-4-methoxybenzoic acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(4'-hydroxy-3'-methoxy-benzylidene)-4-methoxybenzoic acid hydrazide

There total 3 articles about N-(4'-hydroxy-3'-methoxy-benzylidene)-4-methoxybenzoic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-methoxybenzoic acid hydrazide (3290-99-1) + vanillin (121-33-5,8014-42-4) → N-(4'-hydroxy-3'-methoxy-benzylidene)-4-methoxybenzoic acid hydrazide (77218-64-5)

Guidance literature:

With acetic acid; In methanol; for 3h; Reflux;

DOI:10.3390/molecules19011286

Reference yield:

methyl 4-methoxybenzoate (121-98-2) → N-(4'-hydroxy-3'-methoxy-benzylidene)-4-methoxybenzoic acid hydrazide (77218-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 6 h / Reflux

2: acetic acid / methanol / 3 h / Reflux

With hydrazine hydrate; acetic acid; In methanol;

DOI:10.3390/molecules19011286

Reference yield:

→ N-(4'-hydroxy-3'-methoxy-benzylidene)-4-methoxybenzoic acid hydrazide (77218-64-5)

Guidance literature:

/BRN= 3380650/;

upstream raw materials:

4-methoxybenzoic acid hydrazide

vanillin

methyl 4-methoxybenzoate

Downstream raw materials:

4-Methoxy-benzoic acid [1-[4-hydroxy-3-methoxy-5-(4-methyl-piperidin-1-ylmethyl)-phenyl]-meth-(E)-ylidene]-hydrazide