1-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl]-2-(4-methoxyphenoxy)-ethanone

Base Information

Chemical Name:1-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl]-2-(4-methoxyphenoxy)-ethanone
CAS No.:1435951-99-7
Molecular Formula:C₁₈H₂₀N₆O₃S
Molecular Weight:400.461
Hs Code.:

Synonyms:1-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl]-2-(4-methoxyphenoxy)-ethanone

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Chemical Property of 1-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl]-2-(4-methoxyphenoxy)-ethanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl]-2-(4-methoxyphenoxy)-ethanone

There total 4 articles about 1-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl]-2-(4-methoxyphenoxy)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1877-75-4
2-(4-methoxyphenoxy)acetic acid

: 1435953-81-3
7-(piperazin-1-yl)thiazolo[5,4-d]pyrimidin-5-ylamine hydrochloride

: 1435951-99-7
1-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl]-2-(4-methoxyphenoxy)-ethanone

Guidance literature:: 2-(4-methoxyphenoxy)acetic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

7-(piperazin-1-yl)thiazolo[5,4-d]pyrimidin-5-ylamine hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 1435953-79-9
4-[2-amino-6-chloro-5-(formylamino)pyrimidin-4-yl]piperazine-1-carboxylic acid tert-butyl ester

: 1435951-99-7
1-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl]-2-(4-methoxyphenoxy)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: Lawessons reagent / tetrahydrofuran / 1.5 h / 70 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 0 °C

3.2: 12 h / 20 °C

With Lawessons reagent; hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1435953-80-2
4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)piperazine-1-carboxylic acid tert-butyl ester

: 1435951-99-7
1-[4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl]-2-(4-methoxyphenoxy)-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 0 °C

2.2: 12 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; N,N-dimethyl-formamide;