N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide

Base Information Edit

Chemical Name:N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide
CAS No.:171887-03-9
Molecular Formula:C5H4Cl2N4O
Molecular Weight:207.019
Hs Code.:29036990
European Community (EC) Number:425-650-6,605-623-7
DSSTox Substance ID:DTXSID30436651
Nikkaji Number:J3.151.577G
Wikidata:Q72435797
Mol file:171887-03-9.mol

Synonyms:171887-03-9;N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide;N-(2-AMINO-4,6-DICHLOROPYRIMIDINE-5-YL)FORMAMIDE;N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide;2-Amino-4,6-Dichloro-5-FormamidoPyrimidine;MFCD04112936;Formamide, N-(2-amino-4,6-dichloro-5-pyrimidinyl)-;EC 425-650-6;C5H4Cl2N4O;SCHEMBL536664;DTXSID30436651;XYWHZUCZNRMJGO-UHFFFAOYSA-N;BCP22646;BBL030214;STL242902;2,5-diamino-4,6-dichloroformamidohcl;AKOS015854991;AC-1437;AM84604;CS-W015293;SB60473;AS-15705;SY030956;FT-0643648;2-Amino-4,6-dichloro-5-formamido pyrimidine;N-(2-Amino-4,6-dichloro-5-primidinyl)formamide;N-(2-Amino-4,6-dichloro-5-pyrimdinyl)formamide;N-(2-Amino-4,6-dichloro-5-pyrmidinyl)formamide;N-(2-Amino-4,6dichloro-5-pyrimidinyl)formamide;A811363;N-(2-amino-4,6-dichloro-5-pyrimidinyl) formamide;N-(2-amino-4,6-dichloro-pyrimidin-5-yl)-formamide;N-(2-amino-4,6-dichloropyrimidin-5-yl)-formamide;4H-1-Benzopyran-4-one-2,3-dihydro-7-hydroxy-(9CI);N-[2-azanyl-4,6-bis(chloranyl)pyrimidin-5-yl]methanamide

Suppliers and Price of N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
25g
$ 130.00

TCI Chemical
2-Amino-4,6-dichloro-5-formamidopyrimidine >98.0%(HPLC)(N)
25g
$ 123.00

TCI Chemical
2-Amino-4,6-dichloro-5-formamidopyrimidine >98.0%(HPLC)(N)
5g
$ 37.00

Matrix Scientific
N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide 95+%
5g
$ 25.00

Matrix Scientific
N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide 95+%
10g
$ 42.00

Matrix Scientific
N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide 95+%
100g
$ 150.00

Crysdot
N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide 98%
1000g
$ 475.00

Crysdot
N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide 98%
500g
$ 277.00

Chem-Impex
2-Amino-4,6-dichloro-5-formamidopyrimidine,≥98%(HPLC) ≥98%(HPLC)
5G
$ 44.04

Chemenu
N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide 98%
500g
$ 262.00

Total 164 raw suppliers

Chemical Property of N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:4.5 °C
Refractive Index:1.706
Boiling Point:554.77 °C at 760 mmHg
PKA:10.90±0.70(Predicted)
Flash Point:289.315 °C
PSA：80.90000
Density:1.742 g/cm³
LogP:2.22400
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Solubility.:DMSO, Methanol
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:205.9762162
Heavy Atom Count:12
Complexity:158

Purity/Quality:

99% ^*data from raw suppliers

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C(=O)NC1=C(N=C(N=C1Cl)N)Cl
Uses N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide (Abacavir - In House Impurity) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Abacavir intermediate. A purine derivative

Technology Process of N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide

There total 11 articles about N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 2-nitroso-4,6-dichloro-5-formamidopyrimidine

: 171887-03-9
N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In methanol; at 40 ℃; for 4h; under 7500.75 - 11251.1 Torr; Temperature; Autoclave;