6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-ol

Base Information

Chemical Name:6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-ol
CAS No.:1335047-92-1
Molecular Formula:C₂₀H₂₄O₅
Molecular Weight:344.408
Hs Code.:

Synonyms:6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-ol

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Chemical Property of 6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-ol

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Technology Process of 6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-ol

There total 7 articles about 6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1335047-91-0
6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-one

: 1335047-92-1
6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-ol

Guidance literature:: 6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-one; With diisobutylaluminium hydride; In toluene; at -78 ℃; for 1h; Inert atmosphere;

With water; In toluene; at -78 ℃; Inert atmosphere;
DOI:10.1002/chem.201101681

Reference yield:

: 1293991-85-1
6,8-dihydroxy-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-one

: 1335047-92-1
6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 1.17 h / 20 °C / Inert atmosphere

2.1: sodium hydride / dichloromethane; toluene / 0.75 h / 20 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / toluene / 1 h / -78 °C / Inert atmosphere

3.2: -78 °C / Inert atmosphere

With sodium hydride; diisobutylaluminium hydride; potassium carbonate; In dichloromethane; acetone; toluene;
DOI:10.1002/chem.201101681

Reference yield:

: 5673-07-4
2,6-dimethoxytoluene

: 1335047-92-1
6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: aluminum (III) chloride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

1.3: 0 °C

2.1: N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium / tetrahydrofuran; hexane / 0.5 h / -78 - -15 °C / Inert atmosphere

2.2: 3 h / -78 - 20 °C / Inert atmosphere

3.1: camphorsulfonic acid / toluene / 2 h / Reflux; Inert atmosphere

4.1: dichloromethane / 16 h / Inert atmosphere; Reflux

4.2: 20 °C / Inert atmosphere

5.1: potassium carbonate / acetone / 1.17 h / 20 °C / Inert atmosphere

6.1: sodium hydride / dichloromethane; toluene / 0.75 h / 20 °C / Inert atmosphere

7.1: diisobutylaluminium hydride / toluene / 1 h / -78 °C / Inert atmosphere

7.2: -78 °C / Inert atmosphere

With aluminum (III) chloride; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; sodium hydride; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; hexane; dichloromethane; acetone; toluene;
DOI:10.1002/chem.201101681