6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-one

Base Information

Chemical Name:6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-one
CAS No.:1335047-91-0
Molecular Formula:C₂₀H₂₂O₅
Molecular Weight:342.392
Hs Code.:

Synonyms:6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-one

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Chemical Property of 6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-one

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Technology Process of 6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-one

There total 6 articles about 6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1335048-03-7
C₁₈H₁₈O₄

: 107-30-2
chloromethyl methyl ether

: 1335047-91-0
6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-one

Guidance literature:: With sodium hydride; In dichloromethane; toluene; at 20 ℃; for 0.75h; Inert atmosphere;
DOI:10.1002/chem.201101681

Reference yield:

: 1293991-80-6
N-isopropyl-2,4-dimethoxy-3-methylbenzamide

: 1335047-91-0
6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium / tetrahydrofuran; hexane / 0.5 h / -78 - -15 °C / Inert atmosphere

1.2: 3 h / -78 - 20 °C / Inert atmosphere

2.1: camphorsulfonic acid / toluene / 2 h / Reflux; Inert atmosphere

3.1: dichloromethane / 16 h / Inert atmosphere; Reflux

3.2: 20 °C / Inert atmosphere

4.1: potassium carbonate / acetone / 1.17 h / 20 °C / Inert atmosphere

5.1: sodium hydride / dichloromethane; toluene / 0.75 h / 20 °C / Inert atmosphere

With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; sodium hydride; potassium carbonate; In tetrahydrofuran; hexane; dichloromethane; acetone; toluene;
DOI:10.1002/chem.201101681

Reference yield:

: 1293991-81-7
6-(2-hydroxypropyl)-N-isopropyl-2,4-dimethoxy-3-methylbenzamide

: 1335047-91-0
6-(benzyloxy)-8-(methoxymethoxy)-3,7-dimethyl-3,4-dihydro-1H-isochromen-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: camphorsulfonic acid / toluene / 2 h / Reflux; Inert atmosphere

2.1: dichloromethane / 16 h / Inert atmosphere; Reflux

2.2: 20 °C / Inert atmosphere

3.1: potassium carbonate / acetone / 1.17 h / 20 °C / Inert atmosphere

4.1: sodium hydride / dichloromethane; toluene / 0.75 h / 20 °C / Inert atmosphere

With sodium hydride; potassium carbonate; In dichloromethane; acetone; toluene;
DOI:10.1002/chem.201101681