tert-butyl 2-(4-chlorophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate

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Chemical Name:tert-butyl 2-(4-chlorophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate
CAS No.:1002338-92-2
Molecular Formula:C₁₇H₂₂ClN₃O₃
Molecular Weight:351.833
Hs Code.:

Synonyms:tert-butyl 2-(4-chlorophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate

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Chemical Property of tert-butyl 2-(4-chlorophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate

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Technology Process of tert-butyl 2-(4-chlorophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate

There total 5 articles about tert-butyl 2-(4-chlorophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.2%

: 1002338-91-1
tert-butyl 4-[(4-chlorophenyl)carbamoyl]-3-(hydroxymethyl)piperazine-1-carboxylate

: 1002338-92-2
tert-butyl 2-(4-chlorophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In N,N-dimethyl-formamide; toluene; at 20 ℃; for 12h;

Reference yield: 52.0%

: 106-39-8
bromochlorobenzene

: 1246551-25-6
tert-butyl 3-oxo-1,2,5,6,8,8a-hexahydroimidazo[1,5-a]pyrazine-7-carboxylate

: 1002338-92-2
tert-butyl 2-(4-chlorophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium t-butanolate; In toluene; for 24h; Inert atmosphere; Reflux;
DOI:10.1080/00397911.2010.525774

Reference yield:

: 1256815-06-1
di-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)methyl)-piperazine-1,4-dicarboxylate

: 1002338-92-2
tert-butyl 2-(4-chlorophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: methylamine / ethanol / 4 h / Reflux

2: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Reflux

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium t-butanolate / toluene / 24 h / Inert atmosphere; Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydride; methylamine; sodium t-butanolate; In tetrahydrofuran; ethanol; toluene; mineral oil; 1: Mitsunobu reaction / 3: Buchwald-Hartwig coupling reaction;
DOI:10.1080/00397911.2010.525774