ethyl 5-cyano-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-indole-2-carboxylate

Base Information

Chemical Name:ethyl 5-cyano-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-indole-2-carboxylate
CAS No.:1418287-64-5
Molecular Formula:C₂₁H₁₇F₃N₂O₄
Molecular Weight:418.372
Hs Code.:

Synonyms:ethyl 5-cyano-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-indole-2-carboxylate

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Chemical Property of ethyl 5-cyano-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-indole-2-carboxylate

Chemical Property:

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Technology Process of ethyl 5-cyano-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-indole-2-carboxylate

There total 3 articles about ethyl 5-cyano-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105191-13-7
5-Cyano-1H-indole-2-carboxylic acid ethyl ester

: 627902-05-0
2-[4-(trifluoromethoxy)phenoxy]ethanol

: 1418287-64-5
ethyl 5-cyano-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-indole-2-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 20 ℃;

Reference yield:

: 828-27-3
4-Trifluoromethoxyphenol

: 1418287-64-5
ethyl 5-cyano-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

2: triethylamine tris(hydrogen fluoride) / acetonitrile / 3 h / 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

With di-isopropyl azodicarboxylate; caesium carbonate; triethylamine tris(hydrogen fluoride); triphenylphosphine; In N,N-dimethyl-formamide; toluene; acetonitrile; 3: |Mitsunobu Displacement;

Reference yield:

: C₁₅H₂₃F₃O₃Si

: 1418287-64-5
ethyl 5-cyano-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine tris(hydrogen fluoride) / acetonitrile / 3 h / 20 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

With di-isopropyl azodicarboxylate; triethylamine tris(hydrogen fluoride); triphenylphosphine; In toluene; acetonitrile; 2: |Mitsunobu Displacement;