1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-iodo-6-(phenylthio)uracil

Base Information

Chemical Name:1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-iodo-6-(phenylthio)uracil
CAS No.:125057-21-8
Molecular Formula:C₁₉H₂₇IN₂O₄SSi
Molecular Weight:534.49
Hs Code.:

Synonyms:1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-iodo-6-(phenylthio)uracil

Suppliers and Price of 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-iodo-6-(phenylthio)uracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-iodo-6-(phenylthio)uracil

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Technology Process of 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-iodo-6-(phenylthio)uracil

There total 1 articles about 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-iodo-6-(phenylthio)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123027-47-4
1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-6-(phenylthio)uracil

: 125057-21-8
1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-iodo-6-(phenylthio)uracil

Guidance literature:: With 2,2,6,6-tetramethylpiperidinyl-lithium; iodine; Yield given. Multistep reaction; 1.) THF, -70 deg C, 1 h, 2.) -70 deg C, 1 h;
DOI:10.1021/jm00105a055

Reference yield: 52.0%

: 125057-21-8
1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-iodo-6-(phenylthio)uracil

: 125056-92-0
1-(2-Hydroxy-ethoxymethyl)-5-iodo-6-phenylsulfanyl-1H-pyrimidine-2,4-dione

Guidance literature:: With water; acetic acid; In tetrahydrofuran; for 14h; Ambient temperature;
DOI:10.1021/jm00105a055

Reference yield:

: 125057-21-8
1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-iodo-6-(phenylthio)uracil

: 131194-26-8
1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)-5-(2-(Z)-phenylvinyl)uracil

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N, bis(triphenylphosphine)palladium(II) chloride, copper(I) iodide / 1.) THF, 60 deg C, 2 h, 2.) 60 deg C, 1.5 h

2: AcOH, H₂O / tetrahydrofuran / 14 h / Ambient temperature

3: 24 percent / H₂, AcOH / 10percent Pd-BaSO₄ / ethanol / 0.03 h / 760 Torr / Ambient temperature

With copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; water; hydrogen; acetic acid; triethylamine; palladium on barium sulfate; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00105a055