17-(cyclopropylmethyl)-3,6α-bis(benzyloxy)-4,5α-epoxy-14-hydroxymorphinan

Base Information

Chemical Name:17-(cyclopropylmethyl)-3,6α-bis(benzyloxy)-4,5α-epoxy-14-hydroxymorphinan
CAS No.:159465-55-1
Molecular Formula:C₃₄H₃₇NO₄
Molecular Weight:523.672
Hs Code.:

Synonyms:17-(cyclopropylmethyl)-3,6α-bis(benzyloxy)-4,5α-epoxy-14-hydroxymorphinan

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Chemical Property of 17-(cyclopropylmethyl)-3,6α-bis(benzyloxy)-4,5α-epoxy-14-hydroxymorphinan

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Technology Process of 17-(cyclopropylmethyl)-3,6α-bis(benzyloxy)-4,5α-epoxy-14-hydroxymorphinan

There total 3 articles about 17-(cyclopropylmethyl)-3,6α-bis(benzyloxy)-4,5α-epoxy-14-hydroxymorphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 100-39-0
benzyl bromide

: 159465-54-0
17-(cyclopropylmethyl)-3-(benzyloxy)-4,5α-epoxy-6α,14-dihydroxymorphinan

: 159465-55-1
17-(cyclopropylmethyl)-3,6α-bis(benzyloxy)-4,5α-epoxy-14-hydroxymorphinan

Guidance literature:: With potassium hydroxide; tetrabutylammomium bromide; In dichloromethane;

Reference yield:

: 20410-98-4
6alpha-Naltrexol

: 159465-55-1
17-(cyclopropylmethyl)-3,6α-bis(benzyloxy)-4,5α-epoxy-14-hydroxymorphinan

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / aq. NaOH / CH₂Cl₂ / 3.5 h

2: 62 percent / TBABr, 50percent aq. KOH / CH₂Cl₂

With potassium hydroxide; sodium hydroxide; tetrabutylammomium bromide; In dichloromethane;

Reference yield:

: 100-39-0
benzyl bromide

: 159465-55-1
17-(cyclopropylmethyl)-3,6α-bis(benzyloxy)-4,5α-epoxy-14-hydroxymorphinan

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / aq. NaOH / CH₂Cl₂ / 3.5 h

2: 62 percent / TBABr, 50percent aq. KOH / CH₂Cl₂

With potassium hydroxide; sodium hydroxide; tetrabutylammomium bromide; In dichloromethane;