N-Boc-O-allyl-L-tyrosine amide N,N-di-Boc-amide

Base Information

Chemical Name:N-Boc-O-allyl-L-tyrosine amide N,N-di-Boc-amide
CAS No.:147363-13-1
Molecular Formula:C₂₇H₄₀N₂O₈
Molecular Weight:520.623
Hs Code.:

Synonyms:N-Boc-O-allyl-L-tyrosine amide N,N-di-Boc-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Boc-O-allyl-L-tyrosine amide N,N-di-Boc-amide

Chemical Property:

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Technology Process of N-Boc-O-allyl-L-tyrosine amide N,N-di-Boc-amide

There total 5 articles about N-Boc-O-allyl-L-tyrosine amide N,N-di-Boc-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 147363-12-0
tert-butyl (S)-(3-(4-(allyloxy)phenyl)-1-amino-1-oxopropan-2-yl)carbamate

: 147363-13-1
N-Boc-O-allyl-L-tyrosine amide N,N-di-Boc-amide

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jo00058a005

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 147363-13-1
N-Boc-O-allyl-L-tyrosine amide N,N-di-Boc-amide

Guidance literature:: Multi-step reaction with 4 steps

1: i-Pr₂NEt / dimethylformamide / 8 h

2: potassium carbonate, n-Bu₄NI / dimethylformamide / 16 h

3: liquid NH₃ / methanol / 48 h / Ambient temperature

4: 90 percent / i-Pr₂NEt, DMAP, / CH₂Cl₂ / 2 h / Ambient temperature

With dmap; ammonia; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00058a005

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 147363-13-1
N-Boc-O-allyl-L-tyrosine amide N,N-di-Boc-amide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate, n-Bu₄NI / dimethylformamide / 16 h

2: liquid NH₃ / methanol / 48 h / Ambient temperature

3: 90 percent / i-Pr₂NEt, DMAP, / CH₂Cl₂ / 2 h / Ambient temperature

With dmap; ammonia; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00058a005