147363-12-0

Upstream product

• 147363-23-3 methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[4-(prop-2-en-1-yloxy)phenyl]-propanoate 
• 127132-38-1 N-(tert-butyloxycarbonyl)-O-allyl-(S)-tyrosine 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 147363-13-1 N-Boc-O-allyl-L-tyrosine amide N,N-di-Boc-amide 
• 1609554-81-5 tert-butyl (S)-(2-(4-(allyloxy)phenyl)-1-cyanoethyl)carbamate 
• 1609554-82-6 tert-butyl (S)-(2-(4-(allyloxy)phenyl)-1-(1H-tetrazol-5-yl)ethyl)carbamate 
• 147363-14-2 C₃₇H₄₉BrN₂O₁₀ 
• 127802-97-5 (S)-O-allyl-tyrosine methyl ester 

Relevant academic research and scientific papers

MACROCYCLIC COMPOUNDS FOR INHIBITION OF INHIBITORS OF APOPTOSIS

There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

A4 B6 macrotricyclic enantioselective receptors for amino acid derivatives, and other compounds

The subject invention provides chiral receptor molecules having the structure: STR1 wherein A has the structure: STR2 and R1 and R2 are independently the same or different and are H, F, alkyl, aryl, etc.; X is CH2 or NH; Y is C=O or SO2 ; and n is 0 to about 3; which are useful for the purification of enantiomers of amino acid derivatives and other compounds. The subject invention also provides methods of preparing said receptor molecules.

Practical Synthesis of a Highly Enantioselective Receptor for Peptides

A practical synthesis of a highly enantioselective, C3-symmetric host molecule (2) has been developed.The basic strategy is a significant improvement over the relatively lenghty previous synthesis and involves direct addition of a Boc-tyrosine amide anion derivative 4 to methyl 3,5-bis(bromomethyl)benzoate to give an advanced intermediate (5).The final step, a triple macrolactamization, closes three 19-membered rings simultaneously to produce the bridged macrotricyclic receptor in 70-80percent yield.