N-methyl-N-[2-(methylthio)phenyl]-3-(4-nitrophenyl)propiolamide

Base Information

• Chemical Name: N-methyl-N-[2-(methylthio)phenyl]-3-(4-nitrophenyl)propiolamide
• CAS No.: 1198086-57-5
• Molecular Formula: C₁₇H₁₄N₂O₃S
• Molecular Weight: 326.376
• Mol file: 1198086-57-5.mol

Synonyms:N-methyl-N-[2-(methylthio)phenyl]-3-(4-nitrophenyl)propiolamide

Chemical Property of N-methyl-N-[2-(methylthio)phenyl]-3-(4-nitrophenyl)propiolamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of N-methyl-N-[2-(methylthio)phenyl]-3-(4-nitrophenyl)propiolamide

There total 1 articles about N-methyl-N-[2-(methylthio)phenyl]-3-(4-nitrophenyl)propiolamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

p-nitrobenzene iodide (636-98-6) + N-methyl-N-[2-(methylthio)phenyl]propiolamide (1198086-63-3) → N-methyl-N-[2-(methylthio)phenyl]-3-(4-nitrophenyl)propiolamide (1198086-57-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 60 ℃; Inert atmosphere;

DOI:10.1055/s-0029-1217604

Reference yield: 48.0%

N-methyl-N-[2-(methylthio)phenyl]-3-(4-nitrophenyl)propiolamide (1198086-57-5) → 3-iodo-5-methyl-2-(4-nitrophenyl)benzo[b][1,4]thiazepin-4(5H)-one (1198086-70-2)

Guidance literature:

With iodine; In dichloromethane; at 40 ℃; for 24h;

DOI:10.1055/s-0029-1217604

upstream raw materials:

p-nitrobenzene iodide

N-methyl-N-[2-(methylthio)phenyl]propiolamide

Downstream raw materials:

3-iodo-5-methyl-2-(4-nitrophenyl)benzo[b][1,4]thiazepin-4(5H)-one