5-{4-[4-(3-trifluoromethyl-benzyloxy)-phenylamino]-quinazolin-6-yl}-furan-2-carbaldehyde

Base Information

Chemical Name:5-{4-[4-(3-trifluoromethyl-benzyloxy)-phenylamino]-quinazolin-6-yl}-furan-2-carbaldehyde
CAS No.:231278-75-4
Molecular Formula:C₂₇H₁₈F₃N₃O₃
Molecular Weight:489.453
Hs Code.:

Synonyms:5-{4-[4-(3-trifluoromethyl-benzyloxy)-phenylamino]-quinazolin-6-yl}-furan-2-carbaldehyde

Suppliers and Price of 5-{4-[4-(3-trifluoromethyl-benzyloxy)-phenylamino]-quinazolin-6-yl}-furan-2-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-{4-[4-(3-trifluoromethyl-benzyloxy)-phenylamino]-quinazolin-6-yl}-furan-2-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-{4-[4-(3-trifluoromethyl-benzyloxy)-phenylamino]-quinazolin-6-yl}-furan-2-carbaldehyde

There total 6 articles about 5-{4-[4-(3-trifluoromethyl-benzyloxy)-phenylamino]-quinazolin-6-yl}-furan-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98556-31-1
4-chloro-6-iodoquinazoline

: 231278-75-4
5-{4-[4-(3-trifluoromethyl-benzyloxy)-phenylamino]-quinazolin-6-yl}-furan-2-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: propan-2-ol / 70 °C

2: Pd(OAc)2; PPh₃; Et₃N / dimethylformamide

With palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2006.05.090

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 231278-75-4
5-{4-[4-(3-trifluoromethyl-benzyloxy)-phenylamino]-quinazolin-6-yl}-furan-2-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / acetonitrile

2: H₂ / Pt/C / ethanol; tetrahydrofuran

3: propan-2-ol / 70 °C

4: Pd(OAc)2; PPh₃; Et₃N / dimethylformamide

With palladium diacetate; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; platinum on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmcl.2006.05.090

Reference yield:

: 738-58-9
1-((4-nitrophenoxy)methyl)-3-(trifluoromethyl)benzene

: 231278-75-4
5-{4-[4-(3-trifluoromethyl-benzyloxy)-phenylamino]-quinazolin-6-yl}-furan-2-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pt/C / ethanol; tetrahydrofuran

2: propan-2-ol / 70 °C

3: Pd(OAc)2; PPh₃; Et₃N / dimethylformamide

With palladium diacetate; hydrogen; triethylamine; triphenylphosphine; platinum on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2006.05.090