8-[2-(3-chlorophenyl)ethyl]-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yI}carbon yl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

Base Information

Chemical Name:8-[2-(3-chlorophenyl)ethyl]-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yI}carbon yl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one
CAS No.:1401993-28-9
Molecular Formula:C₂₉H₃₁ClF₃N₃O₃
Molecular Weight:562.032
Hs Code.:

Synonyms:8-[2-(3-chlorophenyl)ethyl]-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yI}carbon yl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

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Chemical Property of 8-[2-(3-chlorophenyl)ethyl]-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yI}carbon yl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 8-[2-(3-chlorophenyl)ethyl]-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yI}carbon yl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

There total 5 articles about 8-[2-(3-chlorophenyl)ethyl]-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yI}carbon yl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 16799-05-6
2-(3-chlorophenyl)ethyl bromide

: 3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one, dihydrochloride salt

: 1401993-28-9
8-[2-(3-chlorophenyl)ethyl]-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yI}carbon yl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 1.5h; Microwave irradiation;

Reference yield:

: 617-52-7
Dimethyl itakonate

: 1401993-28-9
8-[2-(3-chlorophenyl)ethyl]-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yI}carbon yl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / tetrahydrofuran / 9 h / 0 - 20 °C

1.2: pH ~ 2

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h

2.2: 16 h

3.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 90 °C / Microwave irradiation

With hydrogenchloride; sodium methylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1401993-28-9
8-[2-(3-chlorophenyl)ethyl]-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yI}carbon yl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / tetrahydrofuran / 9 h / 0 - 20 °C

1.2: pH ~ 2

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h

2.2: 16 h

3.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 90 °C / Microwave irradiation

With hydrogenchloride; sodium methylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;