N-[(S)-6-(2-cyano-ethylamino)-4,5,6,7-tetrahydro-benzothiazol-2-yl]-3-[4-(4-cyano-phenyl)-pyrazol-1-ylmethyl]-benzamide

Base Information

Chemical Name:N-[(S)-6-(2-cyano-ethylamino)-4,5,6,7-tetrahydro-benzothiazol-2-yl]-3-[4-(4-cyano-phenyl)-pyrazol-1-ylmethyl]-benzamide
CAS No.:1373515-61-7
Molecular Formula:C₂₈H₂₅N₇OS
Molecular Weight:507.619
Hs Code.:

Synonyms:N-[(S)-6-(2-cyano-ethylamino)-4,5,6,7-tetrahydro-benzothiazol-2-yl]-3-[4-(4-cyano-phenyl)-pyrazol-1-ylmethyl]-benzamide

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Chemical Property of N-[(S)-6-(2-cyano-ethylamino)-4,5,6,7-tetrahydro-benzothiazol-2-yl]-3-[4-(4-cyano-phenyl)-pyrazol-1-ylmethyl]-benzamide

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Technology Process of N-[(S)-6-(2-cyano-ethylamino)-4,5,6,7-tetrahydro-benzothiazol-2-yl]-3-[4-(4-cyano-phenyl)-pyrazol-1-ylmethyl]-benzamide

There total 7 articles about N-[(S)-6-(2-cyano-ethylamino)-4,5,6,7-tetrahydro-benzothiazol-2-yl]-3-[4-(4-cyano-phenyl)-pyrazol-1-ylmethyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1373515-56-0
N-((S)-6-amino-4,5,6,7-tetrahydro-benzothiazol-2-yl)-3-[4-(4-cyano-phenyl)-pyrazol-1-ylmethyl]-benzamide

: 107-13-1,25014-41-9
acrylonitrile

: 1373515-61-7
N-[(S)-6-(2-cyano-ethylamino)-4,5,6,7-tetrahydro-benzothiazol-2-yl]-3-[4-(4-cyano-phenyl)-pyrazol-1-ylmethyl]-benzamide

Guidance literature:: at 75 ℃; for 24h;

Reference yield:

: 1129-28-8
3-methoxycarbonylbenzyl bromide

: 1373515-61-7
N-[(S)-6-(2-cyano-ethylamino)-4,5,6,7-tetrahydro-benzothiazol-2-yl]-3-[4-(4-cyano-phenyl)-pyrazol-1-ylmethyl]-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / ISOPROPYLAMIDE / 60 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.08 h / 150 °C / Inert atmosphere; Microwave vial

3: water; lithium hydroxide monohydrate / methanol / 20 °C

4: N-ethyl-N,N-diisopropylamine; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane

6: 24 h / 75 °C

With lithium hydroxide monohydrate; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; water; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;

Reference yield:

: 1005628-24-9
3-(4-bromo-pyrazol-1-ylmethyl)-benzoic acid methyl ester

: 1373515-61-7
N-[(S)-6-(2-cyano-ethylamino)-4,5,6,7-tetrahydro-benzothiazol-2-yl]-3-[4-(4-cyano-phenyl)-pyrazol-1-ylmethyl]-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.08 h / 150 °C / Inert atmosphere; Microwave vial

2: water; lithium hydroxide monohydrate / methanol / 20 °C

3: N-ethyl-N,N-diisopropylamine; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane

5: 24 h / 75 °C

With lithium hydroxide monohydrate; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;