methyl (((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)carbamoyl)phenylalaninate

Base Information

Chemical Name:methyl (((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)carbamoyl)phenylalaninate
CAS No.:1229693-88-2
Molecular Formula:C₂₃H₂₉N₃O₅
Molecular Weight:427.5
Hs Code.:

Synonyms:methyl (((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)carbamoyl)phenylalaninate

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Chemical Property of methyl (((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)carbamoyl)phenylalaninate

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Technology Process of methyl (((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)carbamoyl)phenylalaninate

There total 5 articles about methyl (((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)carbamoyl)phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 2900-27-8
(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

: 1229693-88-2
methyl (((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)carbamoyl)phenylalaninate

Guidance literature:: (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid; With sodium azide; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; at 0 ℃; for 0.333333h;

In tetrahydrofuran; toluene; at 45 ℃; Sonication;

methyl (2S)-2-amino-3-phenylpropanoate; In tetrahydrofuran; dichloromethane; toluene; for 1h; Sonication;
DOI:10.1016/j.tetlet.2010.04.002

Reference yield: 85.0%

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: (S)-Nα-(tert-butoxycarbonyl)phenylglycine hydroxamic acid

: 1229693-88-2
methyl (((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)carbamoyl)phenylalaninate

Guidance literature:: (S)-Nα-(tert-butoxycarbonyl)phenylglycine hydroxamic acid; With ethyl 2-(tert-butoxycarbonyloxyimino)-2-cyanoacetate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.25h; Green chemistry;

methyl (2S)-2-amino-3-phenylpropanoate; In dichloromethane; for 6h; chemoselective reaction; Green chemistry;
DOI:10.1002/adsc.201600661

Reference yield:

: 2900-27-8
(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

: 1229693-88-2
methyl (((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)carbamoyl)phenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -20 °C

1.2: 2 h / 0 - 45 °C

2.1: tetrahydrofuran; water / 3 h / 45 °C

With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; water;
DOI:10.1080/00397911003710570