3,5-Bis(benzyl)pyridine

Base Information

• Chemical Name: 3,5-Bis(benzyl)pyridine
• CAS No.: 85665-54-9
• Molecular Formula: C19H17 N
• Molecular Weight: 259.351
• Hs Code.: 2933399090
• European Community (EC) Number: 288-143-7
• NSC Number: 53071
• UNII: JR8WQ1EV1F
• DSSTox Substance ID: DTXSID60234920
• Nikkaji Number: J310.735C
• Wikidata: Q83116772
• Mol file: 85665-54-9.mol

Synonyms:3,5-Bis(benzyl)pyridine;85665-54-9;EINECS 288-143-7;JR8WQ1EV1F;3,5-dibenzylpyridine;NSC-53071;NSC53071;UNII-JR8WQ1EV1F;3,5-bis-(Benzyl)pyridine;3,5-bis(phenylmethyl)pyridine;DTXSID60234920;Pyridine, 3,5-bis(phenylmethyl)-;NSC 53071

Chemical Property of 3,5-Bis(benzyl)pyridine

Chemical Property:

• Vapor Pressure: 1.43E-06mmHg at 25°C
• Boiling Point: 410.5°C at 760 mmHg
• Flash Point: 179.5°C
• PSA: 12.89000
• Density: 1.074g/cm³
• LogP: 4.26320
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 259.136099547
• Heavy Atom Count: 20
• Complexity: 237

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC2=CC(=CN=C2)CC3=CC=CC=C3

Technology Process of 3,5-Bis(benzyl)pyridine

There total 8 articles about 3,5-Bis(benzyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-(3-phenylprop-1-enyl)piperidine (77084-89-0) + 1,3,5-tri-tert-butyl-1,3,5-triazacyclohexane (10560-39-1) → 3,5-dibenzylpyridine (85665-54-9)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; at 200 ℃; for 9h;

DOI:10.1021/jo00189a007

Reference yield: 66.0%

2,3,4,5-tetrahydropyridine N-oxide (34418-91-2) + benzaldehyde (100-52-7) → 3,5-dibenzylpyridine (85665-54-9)

Guidance literature:

With tetrachlorosilane; Hexamethylphosphorous triamide; In 1,2-dichloro-ethane; at 60 ℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;

DOI:10.1016/j.tet.2018.03.038

Reference yield: 58.0%

piperidine (110-89-4) + benzaldehyde (100-52-7) → 3,5-dibenzylpyridine (85665-54-9)

Guidance literature:

benzaldehyde; With Amberlyst 15; In toluene; at 25 ℃; for 0.166667h; Inert atmosphere;

piperidine; In toluene; for 20h; Inert atmosphere; Reflux;

DOI:10.1021/acs.joc.9b03315

upstream raw materials:

N-benzoylpiperidine

benzaldehyde

1-(3-phenylprop-1-enyl)piperidine

1,3,5-tri-tert-butyl-1,3,5-triazacyclohexane

Downstream raw materials:

3,5-dibenzoylpyridine

benzoic acid