N-[2-(2-Bromo-benzoyl)-4-fluoro-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide

Base Information

Chemical Name:N-[2-(2-Bromo-benzoyl)-4-fluoro-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide
CAS No.:186351-08-6
Molecular Formula:C₂₃H₁₄BrFN₂O₄
Molecular Weight:481.278
Hs Code.:

Synonyms:N-[2-(2-Bromo-benzoyl)-4-fluoro-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide

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Chemical Property of N-[2-(2-Bromo-benzoyl)-4-fluoro-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide

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Technology Process of N-[2-(2-Bromo-benzoyl)-4-fluoro-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide

There total 1 articles about N-[2-(2-Bromo-benzoyl)-4-fluoro-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 6780-38-7
N-phthaloylglycine chloride

: 153873-94-0
(2-amino-5-fluorophenyl)(2-bromophenyl)methanone

: 186351-08-6
N-[2-(2-Bromo-benzoyl)-4-fluoro-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide

Guidance literature:: In tetrahydrofuran; for 24h;
DOI:10.1002/(SICI)1099-1344(199612)38:12<1121::AID-JLCR948>3.0.CO;2-V

Reference yield: 71.0%

: 186351-08-6
N-[2-(2-Bromo-benzoyl)-4-fluoro-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide

: 153873-96-2
5-(2-bromophenyl)-7-fluoro-1,3-dihydro-1,4-benzodiazepine-2-one

Guidance literature:: With hydrazine hydrate; In methanol; for 24h;
DOI:10.1002/(SICI)1099-1344(199612)38:12<1121::AID-JLCR948>3.0.CO;2-V

Reference yield:

: 186351-08-6
N-[2-(2-Bromo-benzoyl)-4-fluoro-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide

: 153874-00-1
6-(2-bromophenyl)-8-fluoro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / NH₂NH₂*H₂O / methanol / 24 h

2: 1.) potassium tert-butoxide, diethyl chlorophosphate / 1.) THF, from -20 deg C to 10 deg C, 2.) THF, from -20 deg C to RT, 1.5 h

3: 90 percent / 6 N HCl / 24 h / 90 °C

With hydrogenchloride; potassium tert-butylate; diethyl chlorophosphate; hydrazine hydrate; In methanol;
DOI:10.1002/(SICI)1099-1344(199612)38:12<1121::AID-JLCR948>3.0.CO;2-V