3-Oxo-5-(p-methylbenzylidene)-6-methyl-(4H)-2-pyridazinylacetohydrazide

Base Information

• Chemical Name: 3-Oxo-5-(p-methylbenzylidene)-6-methyl-(4H)-2-pyridazinylacetohydrazide
• CAS No.: 133020-00-5
• Molecular Formula: C₁₅H₁₈N₄O₂
• Molecular Weight: 286.334
• Mol file: 133020-00-5.mol

Synonyms:3-Oxo-5-(p-methylbenzylidene)-6-methyl-(4H)-2-pyridazinylacetohydrazide

Chemical Property of 3-Oxo-5-(p-methylbenzylidene)-6-methyl-(4H)-2-pyridazinylacetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Oxo-5-(p-methylbenzylidene)-6-methyl-(4H)-2-pyridazinylacetohydrazide

There total 5 articles about 3-Oxo-5-(p-methylbenzylidene)-6-methyl-(4H)-2-pyridazinylacetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

Ethyl 3-Oxo-5-(p-methylbenzylidene)-6-methyl-(4H)-2-pyridazinylacetate (132408-01-6) → 3-Oxo-5-(p-methylbenzylidene)-6-methyl-(4H)-2-pyridazinylacetohydrazide (133020-00-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 4h; Heating;

DOI:10.1248/cpb.38.3009

Reference yield:

4-methyl-benzaldehyde (104-87-0) → 3-Oxo-5-(p-methylbenzylidene)-6-methyl-(4H)-2-pyridazinylacetohydrazide (133020-00-5)

Guidance literature:

Multi-step reaction with 4 steps

1: HCl gas / 24 h / Ambient temperature

2: hydrazine hydrate / ethanol / 2 h / Heating

3: 1.) NaOC₂H₅ / 1.) ethanol, 30 min, reflux; 2.) 24 h, reflux

4: 66 percent / hydrazine hydrate / ethanol / 4 h / Heating

With hydrogenchloride; sodium ethanolate; hydrazine hydrate; In ethanol;

DOI:10.1248/cpb.38.3009

Reference yield:

4-Oxo-3-(p-methylbenzylidene)-pentanoic Acid (61713-02-8) → 3-Oxo-5-(p-methylbenzylidene)-6-methyl-(4H)-2-pyridazinylacetohydrazide (133020-00-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 2 h / Heating

2: 1.) NaOC₂H₅ / 1.) ethanol, 30 min, reflux; 2.) 24 h, reflux

3: 66 percent / hydrazine hydrate / ethanol / 4 h / Heating

With sodium ethanolate; hydrazine hydrate; In ethanol;

DOI:10.1248/cpb.38.3009

upstream raw materials:

Ethyl 3-Oxo-5-(p-methylbenzylidene)-6-methyl-(4H)-2-pyridazinylacetate

4-methyl-benzaldehyde

4-Oxo-3-(p-methylbenzylidene)-pentanoic Acid

5-(4-Methylbenzylidene)-6-methyl-(4H)-pyridazin-3-on