61713-02-8Relevant academic research and scientific papers
New organic extractant based on pyridazinone scaffold compounds: Liquid-liquid extraction study and DFT calculations
El Kalai, Fouad,Chelfi, Tarik,Benchat, Noureddine,Hacht, Brahim,Bouklah, Mohamed,Elaatiaoui, Abdelmalek,Daoui, Said,Allali, Mustapha,Ben Hadda, Taibi,Almalki, Faisal
, p. 24 - 31 (2019)
In this work, the synthesis of new organic compounds is reported based on pyridazin-3-(2H)-one compounds. The extraction efficiency of metal ions (e.g. Lead Pb(II), Cadmium Cd(II), Copper Cu(II) and Zinc Zn(II)) from aqueous solutions to organic solutions
Synthesis, structural characterisation and theoretical studies of a novel pyridazine derivative: Investigations of anti-inflammatory activity and inhibition of α-glucosidase
Zaoui, Younes,Ramli, Youssef,Tan, Sang Loon,Tiekink, Edward R.T.,Chemlal, Laila,Mague, Joel T.,Taoufik, Jamal,Faouzi, M. E. Abbes,Ansar, M'Hammed
, (2021)
X-ray crystallography on pyridazine 1 (ethyl 2-(3-methyl-4-(4-methylbenzyl)-6-oxopyridazin-1(6H)-yl)acetate) shows the planar pyridazinyl ring to exhibit significant delocalisation of π-electron density over the constituent atoms and to be substituted wit
Synthesis and pharmacological evaluation in mice of new non-classical antinociceptive agents, 5-(4-arylpiperazin-1-yl)-4-benzyl-1,2-oxazin-6-ones
Bebot, Monique,Coudert, Pascal,Rubat, Catherine,Vallee-Goyet, Danielle,Gardette, Daniel,Mavel, Sylvie,Albuisson, Eliane,Couquelet, Jacques
, p. 659 - 667 (2007/10/03)
Several 5-(4-arylpiperazin-1-yl)-4-benzyl-1,2-oxazin-6-ones have been synthesized and tested for analgesic activity in a visceral pain model (phenylbenzoquinone-induced writhing test=PBQ test). A good correlation has been found between the antinociceptive effects of drugs and both their lipophilic and steric properties. The most active derivatives 5c and 5f, with intraperitoneal ED50 values of 10.5 and 10.3 mg kg-1 respectively, were more extensively investigated by evaluating their analgesic activity in a somatosensory pain model (hot plate test), as well as their sedative properties. Furthermore, naloxone suppressed the effect of 5c and 5f in the PBQ test, though these derivatives were ineffective to potentiate morphine analgesia. Pretreatment with yohimbine did not significantly attenuate the analgesic effects of 5c and 5f. In addition, pretreatment with 5- hydroxytryptophan associated with carbidopa also failed to potentiate the antinociceptive effects of 5c and 5f. So, a part of the analgesic activity of 5c and 5f seems to be related to an opioidergic mechanism, especially at the μ receptor level. Molecular modeling studies performed on the opiate drug morphine and on the most stable conformer of 5f showed structural similarities between these two molecules.
