(3S,4R)-3-benzyloxycarbonylamino-4-iodomethyl-2-oxoazetidine-1-sulphonic acid tetrabutylammonium salt

Base Information

• Chemical Name: (3S,4R)-3-benzyloxycarbonylamino-4-iodomethyl-2-oxoazetidine-1-sulphonic acid tetrabutylammonium salt
• CAS No.: 115887-89-3
• Molecular Formula: C₁₂H₁₂IN₂O₆S*C₁₆H₃₆N
• Molecular Weight: 681.676
• Mol file: 115887-89-3.mol

Synonyms:(3S,4R)-3-benzyloxycarbonylamino-4-iodomethyl-2-oxoazetidine-1-sulphonic acid tetrabutylammonium salt

Chemical Property of (3S,4R)-3-benzyloxycarbonylamino-4-iodomethyl-2-oxoazetidine-1-sulphonic acid tetrabutylammonium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,4R)-3-benzyloxycarbonylamino-4-iodomethyl-2-oxoazetidine-1-sulphonic acid tetrabutylammonium salt

There total 5 articles about (3S,4R)-3-benzyloxycarbonylamino-4-iodomethyl-2-oxoazetidine-1-sulphonic acid tetrabutylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(3S,4R)-3-benzyloxycarbonylamino-4-mesyloxymethyl-2-oxoazetidine-1-sulphonic acid tetrabutylammonium salt (115764-26-6) → (3S,4R)-3-benzyloxycarbonylamino-4-iodomethyl-2-oxoazetidine-1-sulphonic acid tetrabutylammonium salt (115887-89-3)

Guidance literature:

With sodium iodide; In acetonitrile; for 3h; Heating;

Reference yield:

2-benzyloxycarbonylamino-4-O-chloroacetyl-2-deoxy-3-O-mesyl-D-threonamide-N-sulphonic acid tetrabutylammonium salt (92973-31-4) → (3S,4R)-3-benzyloxycarbonylamino-4-iodomethyl-2-oxoazetidine-1-sulphonic acid tetrabutylammonium salt (115887-89-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / KHCO₃ / 1,2-dichloro-ethane; H₂O / 0.5 h / Heating

2: 98 percent / pyridine / 1 h / -20 °C

3: 50 percent / sodium iodide / acetonitrile / 3 h / Heating

With potassium hydrogencarbonate; sodium iodide; In pyridine; water; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

(3R,4R)-3-benzyloxycarbonylamino-4-hydroxymethyl-2-oxoazetidine-1-sulphonic acid tetrabutylammonium salt (115935-89-2) → (3S,4R)-3-benzyloxycarbonylamino-4-iodomethyl-2-oxoazetidine-1-sulphonic acid tetrabutylammonium salt (115887-89-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / pyridine / 1 h / -20 °C

2: 50 percent / sodium iodide / acetonitrile / 3 h / Heating

With sodium iodide; In pyridine; acetonitrile;

upstream raw materials:

(3S,4R)-3-benzyloxycarbonylamino-4-mesyloxymethyl-2-oxoazetidine-1-sulphonic acid tetrabutylammonium salt

(3R,4R)-3-benzyloxycarbonylamino-4-hydroxymethyl-2-oxoazetidine-1-sulphonic acid tetrabutylammonium salt

2-benzyloxycarbonylamino-4-O-chloroacetyl-2-deoxy-3-O-mesyl-D-threonamide-N-sulphonic acid tetrabutylammonium salt

2-benzyloxycarbonylamino-4-O-chloroacetyl-2-deoxy-D-threonamide

Downstream raw materials:

(3S,4R)-3-benzyloxycarbonylamino-4-methyl-2-oxoazetidine-1-sulphonic acid sodium salt

(3S-trans)-2-Oxo-3-[[(phenylmethoxy)carbonyl]amino]-4-methyl-1-azetidinesulfonic acid,tetrabutylammonium salt