N-(benzyloxycarbonyl)-5-isopropenyl-2-(trifluoromethyl)-1,2,3,6-tetrahydropyridine

Base Information

Chemical Name:N-(benzyloxycarbonyl)-5-isopropenyl-2-(trifluoromethyl)-1,2,3,6-tetrahydropyridine
CAS No.:627533-13-5
Molecular Formula:C₁₇H₁₈F₃NO₂
Molecular Weight:325.331
Hs Code.:

Synonyms:N-(benzyloxycarbonyl)-5-isopropenyl-2-(trifluoromethyl)-1,2,3,6-tetrahydropyridine

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Chemical Property of N-(benzyloxycarbonyl)-5-isopropenyl-2-(trifluoromethyl)-1,2,3,6-tetrahydropyridine

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Technology Process of N-(benzyloxycarbonyl)-5-isopropenyl-2-(trifluoromethyl)-1,2,3,6-tetrahydropyridine

There total 2 articles about N-(benzyloxycarbonyl)-5-isopropenyl-2-(trifluoromethyl)-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 627533-10-2
benzyl N-(2-butynyl)-N-[1-(trifluoromethyl)-3-butenyl]carbamate

: 627533-13-5
N-(benzyloxycarbonyl)-5-isopropenyl-2-(trifluoromethyl)-1,2,3,6-tetrahydropyridine

Guidance literature:: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 50 ℃; for 24h;
DOI:10.1021/jo035097x

Reference yield:

: 509093-24-7
4-(benzyloxycarbonyl)amino-5,5,5-trifluoropent-1-ene

: 627533-13-5
N-(benzyloxycarbonyl)-5-isopropenyl-2-(trifluoromethyl)-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.17 h / 0 °C

1.2: 94 percent / dimethylformamide / 5 h / 20 °C

2.1: 75 percent / (Cy₃P)(1,3-Mes₂-imidazolidin-2-yl)RuCl₂(=CHPh) / CH₂Cl₂ / 24 h / 50 °C

With sodium hydride; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo035097x