benzyl N-(2-butynyl)-N-[1-(trifluoromethyl)-3-butenyl]carbamate

Base Information

• Chemical Name: benzyl N-(2-butynyl)-N-[1-(trifluoromethyl)-3-butenyl]carbamate
• CAS No.: 627533-10-2
• Molecular Formula: C₁₇H₁₈F₃NO₂
• Molecular Weight: 325.331
• Mol file: 627533-10-2.mol

Synonyms:benzyl N-(2-butynyl)-N-[1-(trifluoromethyl)-3-butenyl]carbamate

Chemical Property of benzyl N-(2-butynyl)-N-[1-(trifluoromethyl)-3-butenyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of benzyl N-(2-butynyl)-N-[1-(trifluoromethyl)-3-butenyl]carbamate

There total 2 articles about benzyl N-(2-butynyl)-N-[1-(trifluoromethyl)-3-butenyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-Bromo-2-butyne (3355-28-0) + 4-(benzyloxycarbonyl)amino-5,5,5-trifluoropent-1-ene (509093-24-7) → benzyl N-(2-butynyl)-N-[1-(trifluoromethyl)-3-butenyl]carbamate (627533-10-2)

Guidance literature:

4-(benzyloxycarbonyl)amino-5,5,5-trifluoropent-1-ene; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

1-Bromo-2-butyne; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1021/jo035097x

Reference yield:

N-(diphenylmethylene)-1,1,1-trifluoro-4-penten-2-amine (402728-74-9) → benzyl N-(2-butynyl)-N-[1-(trifluoromethyl)-3-butenyl]carbamate (627533-10-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 99 percent / aq. HCl / CH₂Cl₂ / 24 h / 50 °C

2.1: 88 percent / NaHCO₃ / H₂O / 12 h / 20 °C

3.1: NaH / dimethylformamide / 0.17 h / 0 °C

3.2: 94 percent / dimethylformamide / 5 h / 20 °C

With hydrogenchloride; sodium hydride; sodium hydrogencarbonate; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo035097x

Reference yield: 75.0%

benzyl N-(2-butynyl)-N-[1-(trifluoromethyl)-3-butenyl]carbamate (627533-10-2) → N-(benzyloxycarbonyl)-5-isopropenyl-2-(trifluoromethyl)-1,2,3,6-tetrahydropyridine (627533-13-5)

Guidance literature:

tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 50 ℃; for 24h;

DOI:10.1021/jo035097x

upstream raw materials:

1-Bromo-2-butyne

4-(benzyloxycarbonyl)amino-5,5,5-trifluoropent-1-ene

N-(diphenylmethylene)-1,1,1-trifluoro-4-penten-2-amine

Downstream raw materials:

N-(benzyloxycarbonyl)-5-isopropenyl-2-(trifluoromethyl)-1,2,3,6-tetrahydropyridine