benzyl {2-[2-(4-methoxyphenyl)-3-oxo-3H-pyrrolo[1,2-a]indol-9-yl]ethyl}carbamate

Base Information

Chemical Name:benzyl {2-[2-(4-methoxyphenyl)-3-oxo-3H-pyrrolo[1,2-a]indol-9-yl]ethyl}carbamate
CAS No.:1361029-80-2
Molecular Formula:C₂₈H₂₄N₂O₄
Molecular Weight:452.51
Hs Code.:

Synonyms:benzyl {2-[2-(4-methoxyphenyl)-3-oxo-3H-pyrrolo[1,2-a]indol-9-yl]ethyl}carbamate

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Chemical Property of benzyl {2-[2-(4-methoxyphenyl)-3-oxo-3H-pyrrolo[1,2-a]indol-9-yl]ethyl}carbamate

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Technology Process of benzyl {2-[2-(4-methoxyphenyl)-3-oxo-3H-pyrrolo[1,2-a]indol-9-yl]ethyl}carbamate

There total 7 articles about benzyl {2-[2-(4-methoxyphenyl)-3-oxo-3H-pyrrolo[1,2-a]indol-9-yl]ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1361029-79-9
benzyl (2-{1-[2-(4-methoxyphenyl)acryloyl]-1H-indol-3-yl}ethyl)carbamate

: 1361029-80-2
benzyl {2-[2-(4-methoxyphenyl)-3-oxo-3H-pyrrolo[1,2-a]indol-9-yl]ethyl}carbamate

Guidance literature:: With pyridine-3-carbonitrile; oxygen; palladium diacetate; Trimethylacetic acid; In 1,3,5-trimethyl-benzene; at 110 ℃;
DOI:10.1002/anie.201106927

Reference yield:

: 61-54-1
tryptamine

: 1361029-80-2
benzyl {2-[2-(4-methoxyphenyl)-3-oxo-3H-pyrrolo[1,2-a]indol-9-yl]ethyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 12 h / 20 °C / Inert atmosphere

2.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 0.25 h / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: pyridine-3-carbonitrile; oxygen; palladium diacetate; Trimethylacetic acid / 1,3,5-trimethyl-benzene / 110 °C

With pyridine-3-carbonitrile; oxygen; tetra(n-butyl)ammonium hydrogensulfate; palladium diacetate; sodium hydrogencarbonate; sodium hydroxide; Trimethylacetic acid; In dichloromethane; water; 1,3,5-trimethyl-benzene;
DOI:10.1002/anie.201106927

Reference yield:

: 50415-68-4
methyl 2-(4-methoxyphenyl)prop-2-enoate

: 1361029-80-2
benzyl {2-[2-(4-methoxyphenyl)-3-oxo-3H-pyrrolo[1,2-a]indol-9-yl]ethyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / tetrahydrofuran; water / 12 h / 70 °C / Inert atmosphere

2.1: oxalyl dichloride; N,N-dimethyl-formamide

3.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 0.25 h / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

4.1: pyridine-3-carbonitrile; oxygen; palladium diacetate; Trimethylacetic acid / 1,3,5-trimethyl-benzene / 110 °C

With pyridine-3-carbonitrile; oxalyl dichloride; oxygen; tetra(n-butyl)ammonium hydrogensulfate; palladium diacetate; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide; Trimethylacetic acid; In tetrahydrofuran; dichloromethane; water; 1,3,5-trimethyl-benzene;
DOI:10.1002/anie.201106927