benzyl (2-{1-[2-(4-methoxyphenyl)acryloyl]-1H-indol-3-yl}ethyl)carbamate

Base Information

Chemical Name:benzyl (2-{1-[2-(4-methoxyphenyl)acryloyl]-1H-indol-3-yl}ethyl)carbamate
CAS No.:1361029-79-9
Molecular Formula:C₂₈H₂₆N₂O₄
Molecular Weight:454.525
Hs Code.:

Synonyms:benzyl (2-{1-[2-(4-methoxyphenyl)acryloyl]-1H-indol-3-yl}ethyl)carbamate

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Chemical Property of benzyl (2-{1-[2-(4-methoxyphenyl)acryloyl]-1H-indol-3-yl}ethyl)carbamate

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Technology Process of benzyl (2-{1-[2-(4-methoxyphenyl)acryloyl]-1H-indol-3-yl}ethyl)carbamate

There total 5 articles about benzyl (2-{1-[2-(4-methoxyphenyl)acryloyl]-1H-indol-3-yl}ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61-54-1
tryptamine

: 1361029-79-9
benzyl (2-{1-[2-(4-methoxyphenyl)acryloyl]-1H-indol-3-yl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 12 h / 20 °C / Inert atmosphere

2.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 0.25 h / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; sodium hydroxide; In dichloromethane; water;
DOI:10.1002/anie.201106927

Reference yield:

: 23786-14-3
4-methoxy-phenyl acetic acid methyl ester

: 1361029-79-9
benzyl (2-{1-[2-(4-methoxyphenyl)acryloyl]-1H-indol-3-yl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / toluene / 12 h / 80 °C / Inert atmosphere

2.1: potassium hydroxide / tetrahydrofuran; water / 12 h / 70 °C / Inert atmosphere

3.1: oxalyl dichloride; N,N-dimethyl-formamide

4.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 0.25 h / Inert atmosphere

4.2: 2 h / 20 °C / Inert atmosphere

With oxalyl dichloride; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1002/anie.201106927

Reference yield:

: 51747-42-3
2-(4-methoxy-phenyl)-acrylic acid

: 1361029-79-9
benzyl (2-{1-[2-(4-methoxyphenyl)acryloyl]-1H-indol-3-yl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide

2.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 0.25 h / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With oxalyl dichloride; tetra(n-butyl)ammonium hydrogensulfate; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane;
DOI:10.1002/anie.201106927