Technology Process of (3R,4S,5S)-3-amino-5-(3,5-difluoro-4-nitrobenzyl)-4-hydroxytetrahydro-2H-thiopyran 1,1-dioxide hydrochloride
There total 12 articles about (3R,4S,5S)-3-amino-5-(3,5-difluoro-4-nitrobenzyl)-4-hydroxytetrahydro-2H-thiopyran 1,1-dioxide hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
at 25 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/jm300069y
- Guidance literature:
-
Multi-step reaction with 7 steps
1: phosphorus tribromide / 24 h / 25 °C / Inert atmosphere
2: potassium carbonate / acetone / 2.5 h / 25 - 30 °C / Inert atmosphere
3: palladium diacetate; triethylamine; triphenylphosphine / tert-butyl methyl ether / 16 h / 25 °C / Inert atmosphere
4: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -70 °C / Inert atmosphere
5: Chiralpak AD-I / ethanol; n-heptane / Inert atmosphere
6: potassium peroxymonosulfate / tetrahydrofuran; water / 2 h / 40 °C / Inert atmosphere
7: hydrogenchloride / 1,4-dioxane / 2 h / 25 °C / Inert atmosphere
With
hydrogenchloride; lithium aluminium tetrahydride; potassium peroxymonosulfate; palladium diacetate; phosphorus tribromide; potassium carbonate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; ethanol; n-heptane; tert-butyl methyl ether; water; acetone;
DOI:10.1021/jm300069y
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: sodium perborate; acetic acid / 21 h / 65 - 70 °C / Inert atmosphere
2.1: 1-methyl-pyrrolidin-2-one / 6 h / 160 - 165 °C / Inert atmosphere
3.1: thionyl chloride / 0 - 25 °C / Inert atmosphere
4.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 4 h / 0 - 5 °C / Inert atmosphere
4.2: 0.5 h / 25 °C / Cooling with ice; Inert atmosphere
5.1: phosphorus tribromide / 24 h / 25 °C / Inert atmosphere
6.1: potassium carbonate / acetone / 2.5 h / 25 - 30 °C / Inert atmosphere
7.1: palladium diacetate; triethylamine; triphenylphosphine / tert-butyl methyl ether / 16 h / 25 °C / Inert atmosphere
8.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -70 °C / Inert atmosphere
9.1: Chiralpak AD-I / ethanol; n-heptane / Inert atmosphere
10.1: potassium peroxymonosulfate / tetrahydrofuran; water / 2 h / 40 °C / Inert atmosphere
11.1: hydrogenchloride / 1,4-dioxane / 2 h / 25 °C / Inert atmosphere
With
1-methyl-pyrrolidin-2-one; hydrogenchloride; sodium perborate; lithium aluminium tetrahydride; thionyl chloride; potassium peroxymonosulfate; palladium diacetate; phosphorus tribromide; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; ethanol; hexane; n-heptane; tert-butyl methyl ether; water; acetone;
DOI:10.1021/jm300069y
