(3R,4S,5S)-3-((3-(tert-butyl)benzyl)-amino)-5-(3,5-difluoro-4-nitrobenzyl)-4-hydroxytetrahydro-2H-thiothiopyran

Base Information

Chemical Name:(3R,4S,5S)-3-((3-(tert-butyl)benzyl)-amino)-5-(3,5-difluoro-4-nitrobenzyl)-4-hydroxytetrahydro-2H-thiothiopyran
CAS No.:1123173-00-1
Molecular Formula:C₁₇H₂₂F₂N₂O₇S
Molecular Weight:436.434
Hs Code.:

Synonyms:(3R,4S,5S)-3-((3-(tert-butyl)benzyl)-amino)-5-(3,5-difluoro-4-nitrobenzyl)-4-hydroxytetrahydro-2H-thiothiopyran

Suppliers and Price of (3R,4S,5S)-3-((3-(tert-butyl)benzyl)-amino)-5-(3,5-difluoro-4-nitrobenzyl)-4-hydroxytetrahydro-2H-thiothiopyran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,4S,5S)-3-((3-(tert-butyl)benzyl)-amino)-5-(3,5-difluoro-4-nitrobenzyl)-4-hydroxytetrahydro-2H-thiothiopyran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,4S,5S)-3-((3-(tert-butyl)benzyl)-amino)-5-(3,5-difluoro-4-nitrobenzyl)-4-hydroxytetrahydro-2H-thiothiopyran

There total 12 articles about (3R,4S,5S)-3-((3-(tert-butyl)benzyl)-amino)-5-(3,5-difluoro-4-nitrobenzyl)-4-hydroxytetrahydro-2H-thiothiopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1123172-99-5
((3R,4S,5S)-5-(3,5-difluoro-4-nitrobenzyl)-4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-3-yl)carbamate

: 1123173-00-1
(3R,4S,5S)-3-((3-(tert-butyl)benzyl)-amino)-5-(3,5-difluoro-4-nitrobenzyl)-4-hydroxytetrahydro-2H-thiothiopyran

Guidance literature:: With potassium peroxymonosulfate; In tetrahydrofuran; water; at 40 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm300069y

Reference yield:

: 1123172-99-5
((3R,4S,5S)-5-(3,5-difluoro-4-nitrobenzyl)-4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-3-yl)carbamate

: 1123173-00-1
(3R,4S,5S)-3-((3-(tert-butyl)benzyl)-amino)-5-(3,5-difluoro-4-nitrobenzyl)-4-hydroxytetrahydro-2H-thiothiopyran

: C₁₇H₂₂F₂N₂O₆S

Guidance literature:: With oxone; In tetrahydrofuran; water; at 25 ℃;
DOI:10.1016/j.bmcl.2013.07.071

Reference yield:

: 1123172-89-3
(3,5-difluoro-4-nitrophenyl)methanol

: 1123173-00-1
(3R,4S,5S)-3-((3-(tert-butyl)benzyl)-amino)-5-(3,5-difluoro-4-nitrobenzyl)-4-hydroxytetrahydro-2H-thiothiopyran

Guidance literature:: Multi-step reaction with 6 steps

1: phosphorus tribromide / 24 h / 25 °C / Inert atmosphere

2: potassium carbonate / acetone / 2.5 h / 25 - 30 °C / Inert atmosphere

3: palladium diacetate; triethylamine; triphenylphosphine / tert-butyl methyl ether / 16 h / 25 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -70 °C / Inert atmosphere

5: Chiralpak AD-I / ethanol; n-heptane / Inert atmosphere

6: potassium peroxymonosulfate / tetrahydrofuran; water / 2 h / 40 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium peroxymonosulfate; palladium diacetate; phosphorus tribromide; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; ethanol; n-heptane; tert-butyl methyl ether; water; acetone;
DOI:10.1021/jm300069y