(S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(2-((E)-(dimethylamino)methyleneamino)-4-oxo-1,4-dihydropyrimidin-5-yl)pent-4-yn-2-yl 2-cyanoethyldiisopropylphosphoramidite

Base Information

Chemical Name:(S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(2-((E)-(dimethylamino)methyleneamino)-4-oxo-1,4-dihydropyrimidin-5-yl)pent-4-yn-2-yl 2-cyanoethyldiisopropylphosphoramidite
CAS No.:1380603-16-6
Molecular Formula:C₄₂H₅₁N₆O₆P
Molecular Weight:766.877
Hs Code.:

(S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(2-((E)-(dimethylamino)methyleneamino)-4-oxo-1,4-dihydropyrimidin-5-yl)pent-4-yn-2-yl 2-cyanoethyldiisopropylphosphoramidite

Synonyms:(S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(2-((E)-(dimethylamino)methyleneamino)-4-oxo-1,4-dihydropyrimidin-5-yl)pent-4-yn-2-yl 2-cyanoethyldiisopropylphosphoramidite

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Chemical Property of (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(2-((E)-(dimethylamino)methyleneamino)-4-oxo-1,4-dihydropyrimidin-5-yl)pent-4-yn-2-yl 2-cyanoethyldiisopropylphosphoramidite

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Technology Process of (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(2-((E)-(dimethylamino)methyleneamino)-4-oxo-1,4-dihydropyrimidin-5-yl)pent-4-yn-2-yl 2-cyanoethyldiisopropylphosphoramidite

There total 8 articles about (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(2-((E)-(dimethylamino)methyleneamino)-4-oxo-1,4-dihydropyrimidin-5-yl)pent-4-yn-2-yl 2-cyanoethyldiisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380603-06-4
(S,E)-N'-(5-(5-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-hydroxyp ent-1-ynyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-N,N-dimethylformimid amide

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1380603-16-6
(S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(2-((E)-(dimethylamino)methyleneamino)-4-oxo-1,4-dihydropyrimidin-5-yl)pent-4-yn-2-yl 2-cyanoethyldiisopropylphosphoramidite

Guidance literature:: (S,E)-N'-(5-(5-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-hydroxyp ent-1-ynyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-N,N-dimethylformimid amide; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; Inert atmosphere;

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine; In tetrahydrofuran; for 1h;

Reference yield:

: 895153-57-8
(S)-1-(tert-butyldiphenylsilyloxy)-5-(trimethylsilyl)pent-4-yn-2-ol

: 1380603-16-6
(S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(2-((E)-(dimethylamino)methyleneamino)-4-oxo-1,4-dihydropyrimidin-5-yl)pent-4-yn-2-yl 2-cyanoethyldiisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

1.2: Inert atmosphere

2.1: methanol; sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 17 h

4.1: guanidine hydrochloride; sodium ethanolate / ethanol / 1.5 h / 96 °C

5.1: hydrogenchloride / methanol; water / 4 h / 60 °C / Inert atmosphere

6.1: N,N-dimethyl-formamide / 5 h / 40 °C / Inert atmosphere

7.1: pyridine / 5 h / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Inert atmosphere

8.2: 1 h

With pyridine; 1H-imidazole; hydrogenchloride; methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; guanidine hydrochloride; sodium methylate; sodium ethanolate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1380603-19-9
(S,E)-N'-(5-(4,5-dihydroxypent-1-ynyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-N,N-dimethylformimidamide

: 1380603-16-6
(S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(2-((E)-(dimethylamino)methyleneamino)-4-oxo-1,4-dihydropyrimidin-5-yl)pent-4-yn-2-yl 2-cyanoethyldiisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 5 h / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Inert atmosphere

2.2: 1 h

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;