(S,E)-N'-(5-(5-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-hydroxyp ent-1-ynyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-N,N-dimethylformimid amide

Base Information

Chemical Name:(S,E)-N'-(5-(5-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-hydroxyp ent-1-ynyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-N,N-dimethylformimid amide
CAS No.:1380603-06-4
Molecular Formula:C₃₃H₃₄N₄O₅
Molecular Weight:566.657
Hs Code.:

Synonyms:(S,E)-N'-(5-(5-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-hydroxyp ent-1-ynyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-N,N-dimethylformimid amide

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Chemical Property of (S,E)-N'-(5-(5-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-hydroxyp ent-1-ynyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-N,N-dimethylformimid amide

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Technology Process of (S,E)-N'-(5-(5-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-hydroxyp ent-1-ynyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-N,N-dimethylformimid amide

There total 7 articles about (S,E)-N'-(5-(5-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-hydroxyp ent-1-ynyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-N,N-dimethylformimid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380603-19-9
(S,E)-N'-(5-(4,5-dihydroxypent-1-ynyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-N,N-dimethylformimidamide

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1380603-06-4
(S,E)-N'-(5-(5-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-hydroxyp ent-1-ynyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-N,N-dimethylformimid amide

Guidance literature:: With pyridine; for 5h; Inert atmosphere;

Reference yield:

: 895153-57-8
(S)-1-(tert-butyldiphenylsilyloxy)-5-(trimethylsilyl)pent-4-yn-2-ol

: 1380603-06-4
(S,E)-N'-(5-(5-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-hydroxyp ent-1-ynyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-N,N-dimethylformimid amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

1.2: Inert atmosphere

2.1: methanol; sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 17 h

4.1: guanidine hydrochloride; sodium ethanolate / ethanol / 1.5 h / 96 °C

5.1: hydrogenchloride / methanol; water / 4 h / 60 °C / Inert atmosphere

6.1: N,N-dimethyl-formamide / 5 h / 40 °C / Inert atmosphere

7.1: pyridine / 5 h / Inert atmosphere

With pyridine; 1H-imidazole; hydrogenchloride; methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; guanidine hydrochloride; sodium methylate; sodium ethanolate; In methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1380423-86-8
(S)-2,2,3,3,9,9-hexamethyl-8,8-diphenyl-5-(3-(trimethylsilyl)prop-2-ynyl)-4,7-dioxa-3, 8-disiladecane

: 1380603-06-4
(S,E)-N'-(5-(5-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-hydroxyp ent-1-ynyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-N,N-dimethylformimid amide

Guidance literature:: Multi-step reaction with 6 steps

1: methanol; sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 17 h

3: guanidine hydrochloride; sodium ethanolate / ethanol / 1.5 h / 96 °C

4: hydrogenchloride / methanol; water / 4 h / 60 °C / Inert atmosphere

5: N,N-dimethyl-formamide / 5 h / 40 °C / Inert atmosphere

6: pyridine / 5 h / Inert atmosphere

With pyridine; hydrogenchloride; methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; guanidine hydrochloride; sodium methylate; sodium ethanolate; In methanol; ethanol; water; N,N-dimethyl-formamide;