1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-benzimidazole

Base Information

Chemical Name:1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-benzimidazole
CAS No.:1373356-36-5
Molecular Formula:C₂₆H₂₄FN₅O₂S
Molecular Weight:489.573
Hs Code.:

Synonyms:1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-benzimidazole

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Chemical Property of 1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-benzimidazole

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Technology Process of 1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-benzimidazole

There total 12 articles about 1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 502493-47-2
1-(4-fluorophenyl)-1H-benzo[d]imidazole-5-carboxylic acid

: 1373356-64-9
(4-(azetidin-3-yl)piperidin-1-yl)(thiazol-2-yl)methanone

: 1373356-36-5
1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-benzimidazole

Guidance literature:: (4-(azetidin-3-yl)piperidin-1-yl)(thiazol-2-yl)methanone; With triethylamine; HATU; In dichloromethane; at 20 ℃; for 0.5h;

1-(4-fluorophenyl)-1H-benzo[d]imidazole-5-carboxylic acid; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1373356-36-5
1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: tin(II) chloride dihdyrate / ethanol / 4 h / 80 °C

2.2: 20 °C

3.1: N,N-dimethyl-formamide / 5 h / Reflux

4.1: sodium hydroxide / ethanol; water / 96 h / 20 °C

5.1: triethylamine; HATU / dichloromethane / 0.5 h / 20 °C

5.2: 20 h / 20 °C

With tin(II) chloride dihdyrate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1373356-61-6
1-benzyl-4-(1-(tert-butoxycarbonyl)azetidin-3-yl)pyridin-1-ium bromide

: 1373356-36-5
1-(4-fluorophenyl)-5-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; sodium hydrogencarbonate / ethanol / 1.17 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogen; palladium(II) hydroxide / ethanol / 96 h / 20 °C / 2585.81 Torr / Inert atmosphere

3.1: triethylamine / dichloromethane / 0.33 h / 20 °C

3.2: 5 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

5.1: triethylamine; HATU / dichloromethane / 0.5 h / 20 °C

5.2: 20 h / 20 °C

With sodium tetrahydroborate; hydrogen; palladium(II) hydroxide; sodium hydrogencarbonate; triethylamine; HATU; trifluoroacetic acid; In ethanol; dichloromethane;