methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate

Base Information

Chemical Name:methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate
CAS No.:870634-36-9
Molecular Formula:C₁₂H₁₅FO₃
Molecular Weight:226.248
Hs Code.:

Synonyms:methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate

Suppliers and Price of methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 5 raw suppliers

Chemical Property of methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate

Chemical Property:

Boiling Point:321.4±37.0 °C(Predicted)
Density:1.164±0.06 g/cm3(Predicted)

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Methyl 5-(4-Fluorophenyl)-(5S)-hydroxypentanoate is used in preparation of of Ezetimibe and intermediate thereof.

Technology Process of methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate

There total 4 articles about methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 149437-67-2
5-(4-fluorophenyl)-5-oxopentanoic acid methyl ester

: 870634-36-9
methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate

Guidance literature:: 5-(4-fluorophenyl)-5-oxopentanoic acid methyl ester; With sodium t-butanolate; poly(methylhydrosiloxane); (S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; copper(l) chloride; In toluene; at -50 - 0 ℃; for 24.4h; Cooling with isopropanol/dry ice;

With water; acetic acid; In toluene; at -10 - 0 ℃; for 1.5 - 2h; Product distribution / selectivity;