6-{4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-3-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine

Base Information

Chemical Name:6-{4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-3-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine
CAS No.:1062368-41-5
Molecular Formula:C₂₄H₂₆N₆O
Molecular Weight:414.51
Hs Code.:

Synonyms:6-{4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-3-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine

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Chemical Property of 6-{4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-3-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine

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Technology Process of 6-{4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-3-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine

There total 6 articles about 6-{4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-3-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: C₁₉H₁₅ClN₄O

: 1062368-41-5
6-{4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-3-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine

Guidance literature:: With sodium iodide; In N,N-dimethyl-formamide; at 150 ℃; for 0.25h; Microwave irradiation;
DOI:10.1016/j.bmcl.2008.06.052

Reference yield:

: 216661-87-9
4-(4-pyridyl)-1H-pyrazol-3-amine

: 1062368-41-5
6-{4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-3-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / ethanol / 6 h / 110 °C

2: hydrogen bromide; acetic acid / 0.17 h / 130 °C / Microwave irradiation

3: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 140 °C / Microwave irradiation

4: potassium carbonate / sodium iodide / N,N-dimethyl-formamide / 0.25 h / 150 °C / Microwave irradiation

With hydrogen bromide; potassium carbonate; acetic acid; sodium iodide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 103851-89-4
3-(dimethylamino)-2-(4-pyridyl)prop-2-enenitrile

: 1062368-41-5
6-{4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-3-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine monohydrobromide / ethanol; water / 5 h / 110 °C

2: acetic acid / ethanol / 6 h / 110 °C

3: hydrogen bromide; acetic acid / 0.17 h / 130 °C / Microwave irradiation

4: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 140 °C / Microwave irradiation

5: potassium carbonate / sodium iodide / N,N-dimethyl-formamide / 0.25 h / 150 °C / Microwave irradiation

With hydrazine monohydrobromide; hydrogen bromide; potassium carbonate; acetic acid; sodium iodide; In ethanol; water; N,N-dimethyl-formamide;