216661-87-9

Basic information

• Product Name: 4-PYRIDIN-4-YL-2H-PYRAZOL-3-YLAMINE
• Synonyms: 4-PYRIDIN-4-YL-2H-PYRAZOL-3-YLAMINE;4-(4-Pyridinyl)-1H-pyrazol-3-amine;4-(Pyridin-4-yl)-1H-pyrazol-3-amine;4-(pyridin-4-yl)-1H-pyrazol-5-amine
• CAS NO: 216661-87-9
• Molecular Formula: C₈H₈N₄
• Molecular Weight: 160.18
• Mol File: 216661-87-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 413.8°Cat760mmHg
• Flash Point: 233.3°C
• Appearance: /
• Density: 1.315g/cm³
• Vapor Pressure: 4.68E-07mmHg at 25°C
• Refractive Index: 1.673
• PKA: 12.82±0.50(Predicted)
• CAS DataBase Reference: 4-PYRIDIN-4-YL-2H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PYRIDIN-4-YL-2H-PYRAZOL-3-YLAMINE(216661-87-9)
• EPA Substance Registry System: 4-PYRIDIN-4-YL-2H-PYRAZOL-3-YLAMINE(216661-87-9)

Safety Data

• Hazardous Substances Data: 216661-87-9(Hazardous Substances Data)

Usage

Uses

4-(4-Pyridinyl)-1H-pyrazol-3-amine is an reactant used in the synthesis of various pharmaceutical good.

InChI:InChI=1/C8H8N4/c9-8-7(5-11-12-8)6-1-3-10-4-2-6/h1-5H,(H3,9,11,12)

Upstream product

• 13121-99-8 pyridin-4-ylacetonitrile 
• 92333-25-0 pyridin-4-ylacetonitrile hydrochloride 
• 103851-89-4 3-(dimethylamino)-2-(4-pyridyl)prop-2-enenitrile 
• 69512-60-3 cyano-pyridin-4-yl-acetic acid ethyl ester 
• 10445-91-7 4-(Chloromethyl)pyridine 
• 493038-83-8 (Z)-3-(dimethylamino)-2-(4-pyridyl)prop-2-enenitrile 

Downstream Products

• 216661-58-4 3-(pyridin-4-yl)-6-(4-methoxyphenyl)-pyrazolo(1,5-A)pyrimidine 
• 1062368-41-5 6-{4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-3-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine 
• 515880-87-2 6-(4-hydroxyphenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine 
• 597544-21-3 4-(2-(4-(3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenoxy)ethyl)morpholine 
• 866405-64-3 dorsomorphin 

Relevant articles and documents

HERBICIDAL COMPOUNDS

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

THERAPEUTIC COMPOUNDS AND USES THEREOF

The present invention relates to compounds formula (I): and to salts thereof, wherein R1-R4 and A have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of histone demethylases, such as KDM5. Also included are pharmaceutically acceptable compositions comprising the compounds of the present invention and methods of using said compositions in the treatment of various disorders.

Microwave-assisted protocols for the expedited synthesis of pyrazolo[1,5-a] and [3,4-d]pyrimidines

General, high-yielding MAOS protocols for the expedited synthesis of functionalized pyrazolo[1,5-a]pyrimidines and pyrazolo[3,4-b]pyrimidines, as well as their pyrazole precursors, are described amenable to an iterative analogue library synthesis strategy for lead optimization.