3-<<(2R,3S)-3-<(tert-butoxycarbonyl)-amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-4-methyl-5-(trifluoromethyl)-4H-1,2,4-triazole

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Chemical Name:3-<<(2R,3S)-3-<(tert-butoxycarbonyl)-amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-4-methyl-5-(trifluoromethyl)-4H-1,2,4-triazole
CAS No.:141463-21-0
Molecular Formula:C₁₉H₃₁F₃N₄O₃S
Molecular Weight:452.541
Hs Code.:

Synonyms:3-<<(2R,3S)-3-<(tert-butoxycarbonyl)-amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-4-methyl-5-(trifluoromethyl)-4H-1,2,4-triazole

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Chemical Property of 3-<<(2R,3S)-3-<(tert-butoxycarbonyl)-amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-4-methyl-5-(trifluoromethyl)-4H-1,2,4-triazole

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Technology Process of 3-<<(2R,3S)-3-<(tert-butoxycarbonyl)-amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-4-methyl-5-(trifluoromethyl)-4H-1,2,4-triazole

There total 1 articles about 3-<<(2R,3S)-3-<(tert-butoxycarbonyl)-amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-4-methyl-5-(trifluoromethyl)-4H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 30682-81-6
5-mercapto-1-methyl-2-trifluoromethyl-1,3,4-triazole

: 107202-61-9
(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

: 141463-21-0
3-<<(2R,3S)-3-<(tert-butoxycarbonyl)-amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-4-methyl-5-(trifluoromethyl)-4H-1,2,4-triazole

Guidance literature:: With tin(IV) chloride; In tetrachloromethane; for 1h; Ambient temperature;
DOI:10.1021/jm00089a023

Reference yield:

: 141463-21-0
3-<<(2R,3S)-3-<(tert-butoxycarbonyl)-amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-4-methyl-5-(trifluoromethyl)-4H-1,2,4-triazole

: {(S)-1-[(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(4-methyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanyl)-propylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) HCl gas, 2.) triethylamine / 1.) MeOH, RT, 1 h, 2.) CH₂Cl₂

2: 1.) 1-hydroxybenzotriazole hydrate, N,N'-dicyclohexylcarbodiimide / 1.) CH₂Cl₂, 30 min, 2.) CH₂Cl₂, 18 h

3: 64 percent / NH₃ gas / methanol / 2 h / Ambient temperature

With hydrogenchloride; ammonia; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In methanol;
DOI:10.1021/jm00089a023