30682-81-6

Usage

Chemical Properties

LIGHT YELLOW CRYSTALLINE POWDER

InChI:InChI=1/C4H4F3N3S/c1-10-2(4(5,6)7)8-9-3(10)11/h1H3,(H,9,11)

Upstream product

• 6610-29-3 4-methylthiosemicarbazide 
• 25366-21-6 1-trifluoroacetyl-4-methylthiosemicarbazide 

Downstream Products

• 485812-19-9 [CuBr(1,3-propanebis(diphenylphosphine))(4-methyl-5-trifluoromethyl-4H-1,2,4-triazoline-3(2H)-thione)] 
• 485812-18-8 [CuCl(1,3-propanebis(diphenylphosphine))(4-methyl-5-trifluoromethyl-4H-1,2,4-triazoline-3(2H)-thione)] 
• 686289-62-3 [Cu(I)Br(cis-1,2-bis(diphenylphosphino)ethylene)(4-methyl-5-trifluoromethyl-4H-1,2,4-triazoline-3(2H)-thione)] 
• 686289-68-9 [Cu(I)(cis-1,2-bis(diphenylphosphino)ethylene)(4-methyl-5-trifluoromethyl-4H-1,2,4-triazoline-3(2H)-thione)2] 
• 263756-83-8 N-(3-chlorophenyl)-2-{[4-methyl-5-trifluoromethyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide 
• 141463-21-0 3-<<(2R,3S)-3-<(tert-butoxycarbonyl)-amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>-4-methyl-5-(trifluoromethyl)-4H-1,2,4-triazole 

Relevant academic research and scientific papers

Identifying new lead structures to enhance tolerance towards drought stress via high-throughput screening giving crops a quantum of solace

Novel synthetic lead structures interacting with RCAR/(PYR/PYL) receptor proteins were identified based on the results of a high-throughput screening campaign of a large compound library followed by focused SAR studies of the three most promising hit clusters. Whilst indolinylmethyl sulfonamides 8y,z and phenylsulfonyl ethylenediamines 9y,z showed strong affinities for RCAR/ (PYR/PYL) receptor proteins in wheat, thiotriazolyl acetamides 7f,s exhibited promising efficacy against drought stress in vivo (wheat, corn and canola) combined with confirmed target interaction in wheat and arabidopsis thaliana. Remarkably, binding affinities of several representatives of 8 and 9 were on the same level or even better than the essential plant hormone abscisic acid (ABA).

Process and intermediates for the preparation of triazolinones

The invention relates to a new process and to new intermediates for the preparation of triazolinones, most of which are known, of the general formula (I) STR1 in which R1 and R2 have the meanings given in the application, and which can be used as intermediates for the preparation of herbicides and insecticides.

Process for the preparation of triazolinones

The invention relates to a new process and new intermediates for the preparation of triazolinones of the general formula (I) STR1 in which R1 represents in each case optionally substituted alkyl or cycloalkyl and R2 represents amino or in each case optionally substituted alkyl, alkenyl, alkinyl, alkoxy, alkylamino, dialkylamino, cycloalkyl, cycloalkylalkyl or phenyl, and to new intermediates for the preparation of triazolinones, many of which are known and which can be used as intermediates for the preparation of herbicides and insecticides.

Cephalosporin derivatives and bactericides containing the same

Cephalosporin compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof have a broad bactericidal spectrum against various pathogenic bacteria including Psuedomonas aeruginosa and are useful as bactericidal remedies for pathogenic diseases of human and animals: STR1 wherein A represents an unsubstituted or substituted pyridylthio group of a formula (I-1); STR2 or an unsubstituted or substituted pyridiniumthio group of a formula (I-2): STR3 or an unsubstituted or substituted pyridinium group of a formula (I-3); STR4 or a 5- or 6-membered heterocyclicthio or bicycloheterocyclicthio group of a formula (I-4):

Cephalosporin displacement reaction

The present invention is directed to a process for the displacement of the acetoxy group of a cephalosporanic acid by a sulfur nucleophile, in an organic solvent and under essentially anhydrous conditions.