N-[(3-(anilinomethylene)-2-chloro-5-tert-butyl-1-cyclohexen-1-yl)methylene]aniline hydrochloride

Base Information

• Chemical Name: N-[(3-(anilinomethylene)-2-chloro-5-tert-butyl-1-cyclohexen-1-yl)methylene]aniline hydrochloride
• CAS No.: 731863-07-3
• Molecular Formula: C₂₄H₂₇ClN₂*ClH
• Molecular Weight: 415.406
• Mol file: 731863-07-3.mol

Synonyms:N-[(3-(anilinomethylene)-2-chloro-5-tert-butyl-1-cyclohexen-1-yl)methylene]aniline hydrochloride

Chemical Property of N-[(3-(anilinomethylene)-2-chloro-5-tert-butyl-1-cyclohexen-1-yl)methylene]aniline hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(3-(anilinomethylene)-2-chloro-5-tert-butyl-1-cyclohexen-1-yl)methylene]aniline hydrochloride

There total 4 articles about N-[(3-(anilinomethylene)-2-chloro-5-tert-butyl-1-cyclohexen-1-yl)methylene]aniline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

5-(tert-butyl)-2-chloro-3-(hydroxymethylene)cyclohex-1-ene-1-carbaldehyde (61009-99-2) + aniline hydrochloride (142-04-1,36663-09-9) → N-[(3-(anilinomethylene)-2-chloro-5-tert-butyl-1-cyclohexen-1-yl)methylene]aniline hydrochloride (731863-07-3)

Guidance literature:

In methanol; chloroform; for 3.33333h; Heating;

DOI:10.1021/jacs.6b06361

Reference yield: 50.0%

4-tercbutyl-cyclohexanone (98-53-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) + aniline (62-53-3) → N-[(3-(anilinomethylene)-2-chloro-5-tert-butyl-1-cyclohexen-1-yl)methylene]aniline hydrochloride (731863-07-3)

Guidance literature:

4-tercbutyl-cyclohexanone; N,N-dimethyl-formamide; With trichlorophosphate; In dichloromethane; for 3h; Heating / reflux;

aniline; With hydrogenchloride; In ethanol; dichloromethane; water; at 0 ℃;

Reference yield:

4-tercbutyl-cyclohexanone (98-53-3) → N-[(3-(anilinomethylene)-2-chloro-5-tert-butyl-1-cyclohexen-1-yl)methylene]aniline hydrochloride (731863-07-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / 5 °C / Inert atmosphere

1.2: 2 h / 0 - 100 °C / Inert atmosphere

2.1: ethanol / Cooling with ice

With trichlorophosphate; In ethanol;

DOI:10.1039/c8pp00218e

upstream raw materials:

4-tercbutyl-cyclohexanone

N,N-dimethyl-formamide

aniline

5-(tert-butyl)-2-chloro-3-(hydroxymethylene)cyclohex-1-ene-1-carbaldehyde