Technology Process of enkephalin, Arg(2)-Leu(5)-
There total 8 articles about enkephalin, Arg(2)-Leu(5)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanesulfonic acid; methyl-phenyl-thioether; ortho-cresol; trifluoroacetic acid;
at 0 ℃;
for 1h;
DOI:10.1248/cpb.28.2580
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 87 percent / Et3N, DCC / dimethylformamide; tetrahydrofuran / 24 h / Ambient temperature
2: 81 percent / 80percent hydrazine hydrate
3: diazotizing reagent
4: Et3N / dimethylformamide / 48 h / 4 °C
5: 38 percent / methanesulfoniy acid, TFA, thioanisole, o-cresol / 1 h / 0 °C
With
methanesulfonic acid; methyl-phenyl-thioether; diazotizing reagent; hydrazine hydrate; ortho-cresol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.28.2580
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Et3N / dimethylformamide / 48 h / 4 °C
2: 38 percent / methanesulfoniy acid, TFA, thioanisole, o-cresol / 1 h / 0 °C
With
methanesulfonic acid; methyl-phenyl-thioether; ortho-cresol; triethylamine; trifluoroacetic acid;
In
N,N-dimethyl-formamide;
DOI:10.1248/cpb.28.2580
