enkephalin, Arg(2)-Leu(5)-

Base Information

• Chemical Name: enkephalin, Arg(2)-Leu(5)-
• CAS No.: 76939-27-0
• Molecular Formula: C₃₂H₄₆N₈O₇
• Molecular Weight: 654.767
• Mol file: 76939-27-0.mol

Synonyms:Tyr-D-Arg-Gly-Phe-Leu

Chemical Property of enkephalin, Arg(2)-Leu(5)-

Chemical Property:

• PSA: 261.85000
• Density: 1.35g/cm³
• LogP: 2.92410

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of enkephalin, Arg(2)-Leu(5)-

There total 8 articles about enkephalin, Arg(2)-Leu(5)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

Z-Tyr-D-Arg(Mts)-Gly-Phe-Leu-OH (76939-18-9) → H-Tyr-D-Arg-Gly-Phe-Leu-OH (76939-27-0)

Guidance literature:

With methanesulfonic acid; methyl-phenyl-thioether; ortho-cresol; trifluoroacetic acid; at 0 ℃; for 1h;

DOI:10.1248/cpb.28.2580

Reference yield:

Z-L-Tyr-OH (1164-16-5) → H-Tyr-D-Arg-Gly-Phe-Leu-OH (76939-27-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 87 percent / Et₃N, DCC / dimethylformamide; tetrahydrofuran / 24 h / Ambient temperature

2: 81 percent / 80percent hydrazine hydrate

3: diazotizing reagent

4: Et₃N / dimethylformamide / 48 h / 4 °C

5: 38 percent / methanesulfoniy acid, TFA, thioanisole, o-cresol / 1 h / 0 °C

With methanesulfonic acid; methyl-phenyl-thioether; diazotizing reagent; hydrazine hydrate; ortho-cresol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1248/cpb.28.2580

Reference yield:

L-Phe-Leu (3303-55-7) → H-Tyr-D-Arg-Gly-Phe-Leu-OH (76939-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / dimethylformamide / 48 h / 4 °C

2: 38 percent / methanesulfoniy acid, TFA, thioanisole, o-cresol / 1 h / 0 °C

With methanesulfonic acid; methyl-phenyl-thioether; ortho-cresol; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.28.2580

upstream raw materials:

Z-Tyr-D-Arg(Mts)-Gly-Phe-Leu-OH

Z-L-Tyr-OH

L-Phe-Leu

Z(OMe)-Phe-Leu-OH

Refernces