Chemical Property of Propylthiouracil
Chemical Property:
- Appearance/Colour:white crystalline powder
- Melting Point:218-220 °C(lit.)
- Refractive Index:1.609
- Boiling Point:355.2 °C at 760 mmHg
- PKA:pKa 7.8; 8.3 (Uncertain)
- Flash Point:168.6 °C
- PSA：80.74000
- Density:1.24 g/cm3
- LogP:1.38500
- Storage Temp.:Refrigerator
- Solubility.:1.1g/l
- Water Solubility.:1.1 g/L
- XLogP3:0.8
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:2
- Exact Mass:170.05138412
- Heavy Atom Count:11
- Complexity:223
- Purity/Quality:
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98~100.5% *data from raw suppliers
Propylthiouracil *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn,
Xi
- Hazard Codes:Xn,Xi
- Statements:
22-40
- Safety Statements:
36/37-45
- MSDS Files:
-
SDS file from LookChem
Useful:
- Drug Classes:Antithyroid Agents
- Canonical SMILES:CCCC1=CC(=O)NC(=S)N1
- Recent ClinicalTrials:Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE
- Recent EU Clinical Trials:Prospective Randomized Clinical Trial of Total Thyroidectomy (Tx) versus Thionamides (Anti-Thyroid Drugs) in Patients with Moderate-to-Severe Graves’ Ophthalmopathy - a 1-year Follow-up
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Description
Propylthiouracil (PTU) is a thioamide antithyroid agent. It inhibits thyroid peroxidase activity in rat and monkey thyroid microsomes (IC50s = 0.081 and 4.1 μM, respectively). PTU (30 mg/kg) increases thyroid weight and serum thyroid stimulating hormone levels and decreases serum 3,5,3''-triiodothyronine and thyroxine levels in rats. Sensitivity to the bitter taste of PTU is genetically mediated and is associated with increased sensitivity to other sweet and bitter compounds. Formulations containing propylthiouracil have been used in the treatment of Graves'' disease and hyperthyroidism.
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Uses
Antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen antibacterial Antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen.
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Clinical Use
Propylthiouracil is useful in the treatment of hyperthyroidism.There is a delay in appearance of its effects because propylthiouracildoes not interfere with the activity of thyroid hormonesalready formed and stored in the thyroid gland. Thislag period may vary from several days to weeks, dependingon the condition of the patient. The need for three equallyspaced doses during a 24-hour period is often stressed, butevidence now indicates that a single daily dose is as effectiveas multiple daily doses in the treatment of most hyperthyroidpatients.
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Drug interactions
Potentially hazardous interactions with other drugs
None known
